“Overcoming Immune Heterogeneity in Ovarian Cancer” by Dmitriy Zamarin, MD, PhD, Associate Professor, Section Head of Gynecologic Medical Oncology, and Precision Immunology Institute of Icahn School of Medicine at Mount Sinai #ScientificSymposium24

Join us on July 18, 2024 for this exciting one-day workshop at WIS, focusing on the instability of cancer genomes! Registration and abstract submission are now open!

3 and a half years ago, we reported that a partial loss of function VCP mutation results in buildup of tau aggregates causing dementia. Now we have identified small molecule VCP activators that help clear ubiquitinated protein aggregates. doi.org/10.1172/jci169…

PCGI congratulates Dr. Tianpeng Zhang on his new position as Assistant Professor at UVA Medical School!

Excited to share our latest finding: TCAF1, an ion channel regulator, has a novel role in fork protection during replication stress! Huge congrats to Lingzhen, Chen and Shan and all co-authors! Big thanks to David Piston ⚡ Ben Major Nima Mosammaparast for their incredible support!

So excited to share recent work from the Tony Huang lab and my first first-author study! BRCA2 prevents replication stress and transcription-replication conflicts in an early ovarian cancer cell model nature.com/articles/s4146…

We enjoyed a great lineup of talks yesterday for our PCGI Annual Scientific Retreat at the Penn Museum Penn Museum. Huge thanks to our speakers, especially keynote speaker Don Cleveland (UCSD), and faculty keynote speaker Xue Sherry Gao Xue Sherry Gao!

Here is our recent work now published in Nature Communications showing how replication stress and inflammation coordinate with each other during the onset of senescence. Thanks to my mentor Philippe Pasero and current and past members of PaseroLab ! www-nature-com.insb.bib.cnrs.fr/articles/s4146…

Excited to share that our paper on transcription repression after DNA double-strand break is online. Great collaboration with ⁦Taekjip Ha⁩ and ⁦Yang Liu⁩, spearheaded by Shuaixin He ⁦Biophysics Dept@Johns Hopkins Med⁩ ⁦BCMB Graduate Program at JHMI⁩ cell.com/cell-reports/f…

🌟Exciting News!🌟 We are thrilled to share that our recent paper has been published in Nature Communications! Our findings reveal that DCAF15 controls cohesin complex recycling and preserves replication fork integrity to sustain AML cell proliferation. nature.com/articles/s4146…

embopress.org/doi/full/10.10… Excited to share our latest publication in EMBO Journal on TDP1 phosphorylation at S61 in mitosis and genome instability and Cancer. Congratulations Srijita!! for her incredible PhD work. DSTIndia SERB Department of Biotechnology ICMR Indian Association for the Cultivation of Science

I am seeking an enthusiastic postdoc to join my lab in Sydney to work on Nuclear Dynamics, DNA repair and genome stability. We offer innovative science, a competitive salary, and a supportive team. If you are interested, please get in touch with me: [email protected]

The Basser Global Prize honors a visionary scientist who has conceptually advanced BRCA1/2-related research that has led to improvements in clinical care. Nominations will be accepted by 8/16/24! Find nomination package details and more here: spr.ly/6013cxErx Penn Medicine - Abramson Cancer Center

Interested in base damage repair or homologous-recombination or perhaps both? Check out our review where we discuss communication between the two pathways and its implication in therapy response! sciencedirect.com/science/articl… Fantastic job by graduate student Lindsey Aubuchon Washington U. DBBS

Micronuclei are frequently observed in tumor cells as a result of aberrant chromosomal separation. Two new Science studies investigate the cellular processes involved in micronuclear collapse. Learn more in this week's issue: scim.ag/8bF

Super nice and comprehensive perspective in Science Magazine written by CarmineSettembre@lab summarising the papers from my lab and Samuel Bakhoum Melody Di Bona.

Delighted to share our latest preprint where we describe first-in-class DUB #MolecularGlues by Francesca Chandler et al. Another amazing collaboration with Roger Greenberg Professor Francesco Del Galdo and Jo Salvino labs. biorxiv.org/content/10.110…

We screened for DUB inhibitors and identified a hit which did not reproduce -- this turned out to be a 'dirty' well in the library. Instead of dismissing it, we characterised it fully and discovered 1) was a highly selective inhibitor for JAMM-domain DUBs and 2) a molecular glue

Amazing efforts from the first author Francesca Chandler showed the mode of action by #cryoEM where 2 small molecules glue a 16-subunit protein complex. Animation credit Jeroen Claus Phospho

Francesca Chandler Jeroen Claus Phospho In collaboration with Roger Greenberg and Professor Francesco Del Galdo teams we showed molecular glues inhibit interferon signalling in cells. A tour de force effort funded by Wellcome and others, and enabled by our amazing research facilities. The Astbury Centre The Wistar Institute Penn Medicine