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🗓️ #mitoawarenessweek Mitochondria generate the majority of energy for cells. These small organelles were discovered in 1857. Today special dyes are used to study their structure and shape. In this example, super-resolution #microscopy reveals the mitochondrial cristae.#wmdw

Happy to share the preprint of this beautiful collaborative work! Thanks Roberto Zoncu and Hurley Lab!

science.org/doi/10.1126/sc… Excited to share our new work out today in Science Magazine, led by stellar postdoc Regina @hijaishin! We report the discovery of LYCHOS, a candidate cholesterol sensor for the mTORC1 kinase. Below is a brief summary of the story.

🚨New preprint🚨Hurley lab #CryoEM master Chen Cui Zhicheng Cui | 崔志成 presents the TFEBulator mega-complex. His structure identifies a non-canonical structural role for the Rag-Ragulator complexes in the phosphorylation of TFEB by #mTOR.

It’s out! Extrodinary work from Rachel Jansen Rachel Jansen is out today in Science Advances Science Advances

Amazing lab retreat at Donner lake. Grateful to work with this group of brilliant young scientists!

Lactate metabolism is essential in early-onset mitochondrial myopathy science.org/doi/10.1126/sc…

Very excited to see this finally out nature! It's been quite a journey making the story come true and visualizing the megacomplex! Great collaboration Giovanni Napolitano and twitterless Mariana de Araujo and Ballabio and Huber labs!

My amazing lab threw a surprise celebration for my recent promotion to full professor! I'm so grateful and fortunate to work with such smart, creative and caring people. This milestone is theirs as much as mine, and I look forward to helping them achieve ever greater heights!

Thank you ISSNAF and Italy in US for the amazing experience!

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Thrilled to present the structure of mTORC1 on membrane. We are at an exciting time of using SPA to resolve high-resolution structures of complexes that land on the surface of membranes! Looking forward to seeing what can be done for this research frontier in the near future!

Honored to receive the Leonardo Da Vinci Award in Life Sciences from the Leonardo da Vinci Society! Grateful to ISSNAF ISSNAF Bay Area Chapter and the Leonardo da Vinci Society for this prestigious recognition of my work. Thank you for supporting researchers and innovation. #award #lifesciences

🧠 Just out in Nature: A human brain map of mitochondrial diversity. A powerful collaboration with Mosharov and Martin Picard. Big step toward bridging cell biology and neuroimaging! 🔗 nature.com/articles/s4158… 🧬 #MitoBrainMap #neuroscience

Excited to share ‘Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins’, by phenomenal superstar postdoc Aakriti Jain Aakriti Jain and amazing collaborators Rushika M. Perera, Guido Bommer, Charly Craik and James Olzmann: science.org/doi/10.1126/sc…

Online today in nature - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇