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Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP | eLife doi.org/10.7554/eLife.… #CryoEM #antiporter #MembraneProteins

Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics frontiersin.org/articles/10.33…

Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity | Cell Research doi.org/10.1038/s41422… #CryoEM #MembraneProteins

new release1 SpSLC9C1 in lipid nanodiscs apo 8PCZ: dimer 8PD2,3,5,7: protomer state 1-4 w/ cAMP 8PD8: dimer 8PD9: protomer state 1 w/ cGMP 8PDU: dimer 8PDV: protomer "Structures of a sperm-specific solute carrier gated by voltage and cAMP" Paulino lab. Nature.

New preprint from the lab and guess what, it is not about a membrane transporter😱: "Sensory kinase KdpD is a tandem serine histidine kinase controlling K+ pump KdpFABC on the translational and post-transcriptional level". A short thread... 1/4 biorxiv.org/content/10.110…

Cryo-EM structure of TMEM63C suggests it functions as a monomer | Nature Comm disq.us/t/4k6wope #CryoEM #MembraneProteins

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP | Nature Comm disq.us/t/4k7ovfm #CryoEM #ABCtransporter #MembraneProteins

Mimicking the regulatory state of a major facilitator superfamily sugar transporter | eLife doi.org/10.7554/eLife.… #CryoEM #MFStransporter #MembraneProteins

A massive RESOLUTE - Research Empowerment on Solute Carriers collaboration with Centre for Medicines Discovery, #nuvisan, Department of Biochemistry at Oxford University, CeMM, Bayer AG, University of Zurich Work of many many talented colleagues including Syma Khalid, Katharina L. Duerr, Dheeraj Prakaash, Benedikt Kessler, Alvaro Ingles, Giulio Superti-Furga and numerous others

Many SLC superfamily #transporters could be included on this schematic, including organellar Na+/H+ exchangers SLC9A9 and SLC9A6.

Structural basis of anticancer drug recognition and amino acid transport by LAT1 | bioRxiv biorxiv.org/content/10.110…

Uncoupled substrate binding underlies the evolutionary switch between Na+ and H+-coupled prokaryotic aspartate transporters | bioRxiv biorxiv.org/content/10.110…

📢Dear followers! It has been an absolute pleasure to share news on Solute Carriers #SLCs transporters with you during the last 5 years! The RESOLUTE Innovative Health Initiative project is ending soon, but all our resources and datasets are available at re-solute.eu. #CarryTheTorch!

Check out this tour-de-force in technology and assay development by our partners at Novartis, Max Planck Institute for Medical Research, and CeMM: dlvr.it/T7Vyjf

Finally! It is happening! After 6 years of hard work by formidable teams in 13 institutions RESOLUTE - Research Empowerment on Solute Carriers, we have ordered and validated the results and are able to share the FOUR (4) papers aimed at assigning functional properties to each human SLC #membranetransporter

We are excited to kick off our series of 4 manuscripts from the RESOLUTE consortium by sharing the metabolic mapping of the Solute Carrier Superfamily (biorxiv.org/content/10.110…)!

Do you want to know with which proteins an SLC membrane transporter socializes? Our RESOLUTE - Research Empowerment on Solute Carriers series of 4 manuscripts continues, and we are excited to share the so far most comprehensive interactome mapping of solute carriers biorxiv.org/content/10.110…

We are thrilled to share the THIRD study of our series which sheds light on the genetic interactions between transporters and links them to the metabolic network: doi.org/10.1101/2024.1…

Are you curious what is known about SLCs? And how they are related? We are enthusiastic to wrap up the series of four (4) manuscripts by presenting the data- and knowledge-derived functional landscape of human solute carriers #SLC : biorxiv.org/content/10.110…

Paper(s) alert from our RESOLUTE - Research Empowerment on Solute Carriers project – In a compilation of four papers in Molecular Systems Biology we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters