New preprint from my colleagues and I describing automated and sequential genetic manipulations via and engineered Cas9 system #CRISPR #syntheticbiology dlvr.it/RZ3QGL.

It is hard to imagine 274 characters more damaging to US efforts to provide medicines for #COVID19 patients, and to provide vaccines for all of us. Sowing distrust of those who work tirelessly to ensure the safety and efficacy of our medicines and vaccines will kill Americans.

Science is not political. It is not an opponent who can be defeated. Science is simply a philosophy that considers all ideas but moves forward those supported by the best evidence. Battling science is like battling gravity. Doing so during a pandemic is deadly & self-destructive.

Today was a very, very odd day I testified before @senatehomeland They held a hearing on hydroxychloroquine. Yup, HCQ In the middle of the worst surge of pandemic HCQ It was clear how our information architecture shapes questions of science and medicine of COVID A thread

Incredible work!

No words needed. That's what vaccines do.

Online Now: Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities dlvr.it/RpYD1c

Read the latest issue cell.com/molecular-cell…

Our paper is officially out in the latest issue of Molecular Cell

Video of #SARSCoV2 infecting brain cells (gray blobs) with cell fusion, hijacking, and explosive release of copies for more invasions nytimes.com/2021/08/22/sci… NYT Science Andrew Jacobs by Sophie Aicher and Planas Delphine Institut Pasteur, since 1887 justsaysinrats Nikon Small World

Thank you @tool for spending 1,227 minutes with me this year on Spotify. You are my #1. #SpotifyWrapped open.spotify.com/artist/2yEwvVS…

Why cell therapy is so cool.

Here's a bacterium on a diatom on an amphipod on a frog on a bump on the log in the hole in the bottom of the sea [source, read more: bit.ly/2F8fbBC]

Very excited to see our work on Cas9 conformational activation out in nature ! nature.com/articles/s4158… What started as a very poor crystal structure back in 2017 in the @MartinJinek lab, turned into a full blown cryoEM project during the pandemic.

The pioneer of DNA assembly EcoRI + DNA ligase* = the first recombinant plasmid

Thank you for the great article ⁦⁦MedCity News⁩ medcitynews.com/2023/09/startu…

The story behind how Generation 3.0 proGuides were engineered. They enable efficient, multi-step, pre-programmed CRISPR activation of endogenous genes. biorxiv.org/content/10.110…