Excited to share our updated HiDRO paper in @nature rdcu.be/dgGge! We used HiDRO to screen for druggable regulators of 3D genome folding. We further characterized a novel noncanonical function of GSK3A in regulating cohesin. Brief summary highlighting what’s new: 1/

Very excited to see our work on using gene features to identify target GWAS genes out at Nature Genetics

Thank you!!! Honored to be a Tufts GSBS Rosenberg Fellow 🥳 Grateful for the nomination from my program and the endless support from my PI and lab ☺️ Ryan Tewhey Tewhey Lab

This is by far the most convincing regulatory DNA synthetic design paper to date. Congrats to the authors 1/

Had a great time hanging out with the Tewhey Lab ! Thanks Ryan Tewhey and The Jackson Laboratory for hosting us!

After a constructive set of reviews, our single-cell reporter work is OUT nature.com/articles/s4159… Check out the briefing if you want the tldr nature.com/articles/s4159… I am particularly fond of some of the new applications. Mini-update.

Two excellent sets of take-home impressions from Sohini Ramachandran and Ewan Birney on #BoG24. I'm going home excited and inspired by the science presented this week. A few impressions from me 1/

Fantastic scMPRA approach from Jean-Benoît (JB) Lalanne, Samuel Gabriel Regalado & Jay Shendure. Lots of great observations buried in the supplemental too!

Using #AI, a Broad/The Jackson Laboratory /Yale School of Medicine team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. broad.io/CRE-AI Steve Reilly

🔥🔥🔥 new paper out from Steven Reilly Steve Reilly together with Ryan Tewhey Ryan Tewhey led by Sager Gosai Sager Gosai + Rodrigo Castro Rodrigo I Castro Synthetic cis-regulatory elements (CREs) that drive cell-type-specific gene expression 🧬🤯 nature.com/articles/s4158…

Excited to share our sequence design work published in nature. I had the privilege of co-leading this effort alongside my friend and colleague Sager Gosai under the supervision of Ryan Tewhey, Steve Reilly, and Pardis Sabeti nature.com/articles/s4158… 1/7

Excited to share our latest preprint, as part of ENCODE4, on a consensus variant-to-function (cV2F) score for functionally prioritizing variants for complex disease - led by Tabassum Fabiha and co-mentored with Alkes Price. biorxiv.org/content/10.110…