Congratulations! Predictive coding all the way down! That should include deeper, faster scales in dendrites and soma of neurons where microtubules are in mixed polarity, anti-parallel networks so information flows in opposite directions. This is perfect for predictive coding and

Excellent review on transmodal association hubs — essential for understanding brain evolution, development, and highly relevant for psychedelic research

Mitochondrial origins of the pressure to sleep nature.com/articles/s4158…

New preprint: arxiv.org/abs/2508.11423 "Open Questions about Time and Self-reference in Living Systems" by Samson Abramsky, Wolfgang Banzhaf, Leo S. D. Caves, Michael Levin, Penousal Machado, Charles Ofria, Susan Stepney, Roger White

Congrats to Parker Singleton & the SYPRES team! Launched today, SYPRES is a living meta-analysis on psilocybin for depression, built with open science tools to bridge research gaps. Amazing work!

microdosing 🍄

Rubicon, crossed

How your brain's metabolic waste products get cleared during sleep, featuring the pivotal 2012 discovery of glymphatics Scientific American Lydia Denworth scientificamerican.com/article/how-sl…

A DMT Quest.

Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum | Nature Communications nature.com/articles/s4146…

Inside the search for a universal signature of unconsciousness bigthink.com/neuropsych/unc… "Neuroscientists like Earl K. Miller argue that the brain’s coordinated waves do the real work" #neuroscience MIT Picower Institute MIT Brain and Cognitive Sciences Massachusetts Institute of Technology (MIT)

Psychedelics and the Brain: Unlocking New Possibilities for Healing youtube.com/live/cil9mLO-m… via YouTube Grateful to my charming hosts The Aspen Institute and the charming Jon Hamilton. This warms up as it goes on... #psychedelics

Resting-state fMRI reveals recurrent attractor-like states. In MDD, a salience-dominated state occurs more often with shorter dwell times, linked to anhedonia. Transitions show reduced flexibility between cognitive–affective systems and costly detours along inefficient structural

Case report: Significant lesion reduction and neural structural changes following ibogaine treatments for multiple sclerosis pmc.ncbi.nlm.nih.gov/articles/PMC11…

Keep an eye on this scientist

Having good health is not just to live longer... "When health is absent, wisdom cannot reveal itself, strength cannot fight, intelligence cannot be applied, art cannot become manifest, wealth becomes useless," Greek physician Herophilus