Congrats to the teams Amgen 🧪🔬🧬 & Plexium for an impressive piece of work. After work by Novartis now providing additional proof that VHL is glueable. The way the team followed through with this study is scientifically amazing. #TPD #proximity

I thought this paper from Ryan Potts group at Amgen was fascinating. biorxiv.org/content/10.110… It has everything: Chemical induced proximity focused DELs on beads, small decorations on solvent exposed portions of known binder, one bead per well, photocleavable linkers to

.Ryan Potts Amgen 🧪🔬🧬 demonstrate proof-of-concept of disease-specific targeted degradation by redirecting virally encoded E3 ubiquitin ligases with VIPER-TACs. dlvr.it/TJgF11

Bacterial ubiquitin ligase engineered for small molecule and protein target identification biorxiv.org/content/10.110… #biorxiv_molbio

Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules biorxiv.org/content/10.110… #biorxiv_biochem

DEL is accelerating our Induced Proximity Platform—helping us discover small molecules that rewire cellular processes and bind challenging targets. A powerful example of DNA driving therapeutic innovation. #DNADay #MyCompany

Very cool!

Excited to announce a new collaboration between the Molecular Therapeutics Initiative (MTI) and Amgen Inc.! This partnership includes funding for cutting-edge research & an internship program for grad students to train in drug discovery & development at Amgen. #MTI #Amgen

Happy to present our latest paper with Ryan Potts & Amgen 🧪🔬🧬 in J. Am. Chem. Soc. by co-first authors Charlotte Zammit & Cory Nadel on the discovery of a direct-acting covalent destabilizing degrader of AR and the undruggable truncation variant of AR, AR-V7, in androgen-independent prostate

🎓 Recent STEM grad? Jump-start your PhD journey with Amgen’s new 2-yr paid Postbaccalaureate Research Fellowship in Thousand Oaks! Work with world-class scientists, publish your findings, and make a real impact for patients. Apply by July 15 ➡️ amgen.wd1.myworkdayjobs.com/Careers/job/US…

What a mind-blowing week for AI in biology! 🚀 Xaira just dropped the largest genome-wide perturbation dataset ever last week 🧬 Arc unveiled STATE yesterday, the most powerful foundation model for single-cell perturbation prediction 🧠 DeepMind followed up with AlphaGenome,

Ryan Potts Amazing opportunity for recent STEM grads! A paid 2-year fellowship at Amgen with real research, publication potential, and impact on patients

Ray Deshaies has a new piece in Nature Reviews Drug Discovery on how multispecific drugs are reshaping pharmacology. During his time at Amgen 🧪🔬🧬, Ray challenged us to rethink what molecules could do, especially with induced proximity. #MyCompany nature.com/articles/s4157…

The passing Of Dave Mangelsdorf is a terrible loss for his family, friends and the science world. Davo will never be forgotten. 😢 chapelgazette.cfd/david-mangelsd…