Attenuating global translation with low doses of cycloheximide (CHX) also reversed P67L VX-445 response.

We concluded translational dynamics modulate the co-translational folding of P67L sufficiently to sensitive it to VX-445. Personalized medicine will need to account for system level changes beyond single point mutations in targets.

Follow Jonathan Davies’s research activities in Peru:

Congrats Dongsheng Han and @JaredNordman! Glad that Jonathan Davies and our lab could contribute to this exciting paper.

Good morning Phoenix. Looking forward to attending #NACFC2023. If you’re around, come to the lunch roundtable on Proteomic-driven Advances in Studies of CF (RT29) where we’ll discuss the latest mass spec research on CF. Cystic Fibrosis Foundation

Congratulations Eli Fritz McDonald !