The interest in elevated remnant cholesterol as a direct cause of atherosclerotic cardiovascular disease had a slow start; however, interest has increased enourmously recently among scientists and pharma companies. The term was first used in 2007 in a JAMA paper. Stay tuned!

Elevated plasma triglycerides are associated with increased risk of later psoriasis in both observational and causal, genetic analyses. Novel discovery in 100,000 individuals from the Copenhagen General Population Study academic.oup.com/bjd/advance-ar… academic.oup.com/bjd/advance-ar…

This is a medical first- despite drug approvals for TG >500, none were shown to reduce pancreatitis. The Balance study required great science, a great drug, great study design, and great execution to succeed. Congrats to Ionis for 15 yrs of dedication and perseverance to

#glycotime ...and the 2024 President’s Innovator Award to be presented at SFG '24 (sfg.memberclicks.net/2024-annual-me…) goes to Dr. Jeff Esko, UCSD. HUGE CONGRATS JEFF!!

#AcademicChatter #AcademicX

Glycans play an important role in modulating the interactions between natural killer cells and antibodies to fight pathogens and harmful cells. elifesciences.org/articles/10242…

Elevated remnant cholesterol remains a likely cause of ASCVD in diabetes. Remnant cholesterol-lowering therapies should also lower apoB levels to reduce risk of ASCVD: rdcu.be/dVQJg Risk of ASCVD in diabetes in the Copenhagen General Population Study:

Trainees- don’t miss this opportunity to come to beautiful SLC, give a talk in a Rising Stars Symposium, and train and start experiments/collaborations in one of our four fantastic cores!!

In impaired renal function on statins, elevated remnant cholesterol (but not LDL-C) explains most residual risk of ASCVD: ahajournals.org/doi/full/10.11… Such patients are identifiable through higher non-HDL cholesterol or apoB levels. Without statins, elevated LDL-C also matter

A component of human milk with anti-inflammatory properties. insight.jci.org/articles/view/… Ariane Pessentheiner, Spann, et al. show benefit of this oligosaccharide in an atherosclerosis model. Philip Gordts @Dr_LarsBode UC San Diego School of Medicine

Happy to share that our work with @Dr_LarsBode Ariane Pessentheiner Glass Lab on how specific #glycans in human milk can be leveraged to reduce chronic inflammation and #atherosclerosis development is published in JCI Insight - insight.jci.org/articles/view/…

Check out our collaborative work on GPNMB in cardiac repair with Arjun Debb and Jake Lusis UCLA. Together we identified GPNMB as the first protein ligand for orphan receptor GPR39 and uncovered its involvement in post myocardial repair of the heart. go.nature.com/40kBJKS

Looking to recruit a lab research coordinator employment.ucsd.edu/research-coord…

Busy week - Just out in Cell Metabolism: The work with the Metallo lab Salk Institute showing that trans-fat promotes hepatic serine palmitoyltransferase flux (SPT), VLDL secretion, and #atherosclerosis. SPT inhibition reduces VLDL and atherosclerosis. sciencedirect.com/science/articl…

Are you a trainee interested in glycobiology? Join us (@fiona_chembot) for the Glycobiology Gordon Research Seminar, March 22-23, 2025 in Italy! grc.org/glycobiology-g… Submit abstracts by Dec. 15 to be considered for a talk! #glycotime

Hello everyone! I am helping to organize a one-day symposium on fluorescent metabolite biosensors and their use in metabolism research. It will be May 12-13 and associated with the Cold Spring Harbor Laboratory “Mechanisms of Metabolic Signaling” Symposium. Our field needs to be

First time doing a X-tweetorial on our manuscript, be kind ! Our latest work in Nature Metabolism uncovers a striking role for glycogen accumulation in lung adenocarcinoma (LUAD) using spatial metabolomics & MALDI imaging. A thread 🧵 (1/)

Big news: I’ve joined the University of Utah University of Utah as an Associate Professor in the Department of Pathology, Division of Microbiology and Immunology University of Utah Microbiology & Immunology! Advancing glycobiology-driven research in metabolism and inflammation. Grateful to my UCSD colleagues. #Glycotime

My divisions is hiring faculty! Let me know if you are interested in applying or have questions.