Lewis Lab (@peterlewislab) 's Twitter Profile
Lewis Lab

@peterlewislab

Chromatin Biochemistry and Genomics Research Group
@UWMadison @UWSMPH @BMC_UW

ID: 1109193493606526976

linkhttp://TheLewisLab.net calendar_today22-03-2019 20:41:51

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Lewis Lab
@peterlewislab

a month ago

Domain analysis identifies a discrete nucleic acid-binding domain (NBD) within SUZ12 responsible for constraining PRC2 activity. CryoEM studies showed the NBD in close proximity to nucleic acids. Loss of this region (NEC, VEFS) causes global H3K27me3 hypermethylation. 11/13

Domain analysis identifies a discrete nucleic acid-binding domain (NBD) within SUZ12 responsible for constraining PRC2 activity. CryoEM studies showed the NBD in close proximity to nucleic acids. Loss of this region (NEC, VEFS) causes global H3K27me3 hypermethylation. 11/13