What a Polygenic Risk Score Can and Can't Tell You magazine.hms.harvard.edu/articles/what-… Harvard Magazine Mass General Heart Broad Institute Harvard Medical School

Charlie Fuchs, Roche's head of oncology said “from a commercial standpoint, there’s an easier path forward to consider when it’s a highly prevalent cancer like breast cancer." Pancreatic cancer is the 3rd leading cause of cancer-related deaths in US. 5 yr survival rate is 12%.

An estimated 64,050 Americans will be diagnosed with pancreatic cancer in 2023. Approx. 50,550 Americans are expected to die from #pancsm this year h/t PanCAN Current goal is to increase 5 year survival rate from 12% to 20% by 2030:

Redwood City, CA-based Revolution Medicines & CEO Mark Goldsmith are incl in story as 1 of the few clinical stage biopharma companies working on new treatments for pancreatic cancer. Genentech & BioNTech are collaborating on a #pancsm vaccine in early stage development. $RVMD

Exclusive: Noetik, a Bay Area startup led by two ex-Recursion executives, has raised a $40 million Series A I talked with Ron Alfa and the round’s lead investor, Amy Schulman @ Polaris: e.endpointsnews.com/t/t-l-sopud-ji…

See below for the answer to how much the placebo costs with insurance....

I think this is to reduce the significant amount of fraud that Johnson & Johnson (and other manufacturers face ). Every single meeting I have had with a drug mfg has included a discussion about 340b fraud amounting to tens of millions of dollars or more. It looks like JJ is just

"In at least 12 of the 19 states where Acadia operates psychiatric hospitals, dozens of patients, employees & police officers alerted authorities that the company was detaining people in ways that violated the law....judges have intervened to force Acadia to release patients."

"at Acadia, patients were often held for financial reasons rather than medical ones, according to more than 50 current & former executives & staff members...."

"Acadia, which charges $2,200 a day for some patients, at times deploys an array of strategies to persuade insurers to cover longer stays, employees said. Acadia has exaggerated patients’ symptoms...Unless the patients or their families hire lawyers, Acadia often holds them

"At Acadia facilities around the country, health inspectors have found that some patients did not receive therapy, were unsupervised or were denied access to vital medications. Many inspection reports described rapes, assaults & filthy conditions."

"With its stock price rising, Acadia is valued at about $7B. Its chief executive was paid more than $7M last year....Acadia said it had tentatively agreed to settle a Justice Department investigation into, among other things, whether patient stays were medically necessary." $ACHC

"employees at Acadia hospitals in Ohio and Michigan complained to their state regulators that doctors had written false statements in patients’ medical charts to justify continuing their stays." $ACHC

"at an Acadia hospital in Missouri, 3 former nurses said, executives pressured them to label patients whose insurance was about to run out as uncooperative. Acadia employees then would argue to insurance companies that the patients weren’t ready to leave. Sometimes, the nurses

Europe's top court, European Court of Justice, said the European Commission had no grounds to work to prevent Illumina's $8B acquisition of the cancer screening start-up Grail (spun out of Illumina as new startup in '15) in '21.ft.com/content/57e9c3…

"Antitrust regulators in Brussels had probed the acquisition despite Grail having no revenues or presence in the EU, usually a requirement for transactions to be investigated, & ultimately forced Illumina to spin off Grail in June [2024]."

"The decision by the European Court of Justice supersedes the [European] commission’s earlier decision to block the deal. Illumina said a €432mn fine levied against it for completing the takeover without Brussels’ approval would no longer be payable." $ILMN

"The commission opened its probe into the transaction in July 2021 under a rule that allows it to review mergers if member states have requested it, even if it the deal falls below its usual revenue threshold. It blocked the tie-up just over a year later, ruling it would stifle

"And then, one by one, they were canceled Our responsibility wasn’t just to pave the way for women, but to do it perfectly — and when we weren’t examples of whatever warped mutation the word Girlboss (which is now immortalized in the Merriam-Webster dictionary) had come to