🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

1/ Can Large Language Models (LLMs) truly reason? Or are they just sophisticated pattern matchers? In our latest preprint, we explore this key question through a large-scale study of both open-source like Llama, Phi, Gemma, and Mistral and leading closed models, including the

Now online: We created de novo insulin receptor agonists using computational protein design! Choi Lab Xiaochen Bai Preetham Venkatesh Institute for Protein Design #BakerLab biorxiv.org/content/10.110…

If you are a technical person (engineer, quant, mathematician) interested in learning biology, I encourage you to hit textbooks and memorize the "things", eg. cytokines, surface proteins, cell types, pathways, in core fields like immunology. You will be averse to this because

Tech founders after watching Starship

This is an ice core from West Antarctica. The black ring on it is a layer of volcanic ash deposited some 21,000 years ago. This and other ice cores can help us to learn about the past, including Phoenician and Roman history🧵

Claude Sonnet is the best interface for matplotlib.

Join me for the Bonnie Berger Lab seminar on Wednesday where I'll be talking about #PoET, shrinking protein language models, and protein engineering OpenProtein.AI!

That deep anxiety when you hit play on the validation run / open wandb and wait for the metrics to load. The universe has decided whether your work was good and now the result is about to be revealed to you.

When you call a business and the automated answer goes on about hours, location etc. Very annoying. If I’m calling it’s because I want info that I can’t just look up online.

Just IPD things ❤️ Another 160 gpus, brings the internal cluster up to 1079 gpus total.

Madrid’s metro was 71 miles long in 1995. That would be the world’s 51st longest today, reasonable considering Madrid is the 57th largest city by population. Yet over 12 years, the metro would ~3x in length at costs much lower than was thought possible. Here’s how they did it🧵

this looks unreal

i rabbit-holed into the Genesis Sim codebase because the website is hypey and unclear; and I didn't want to just blindly retweet. It's basically like Mujoco but with more advanced materials/rendering/solvers, written all in Python thanks to being powered by Taichi, which makes it

Great post, cryo is so cool.

Ok anyone else notice Claude has been nerfed recently?

Basically the customer support experience with any Google produce. Idk what they are doing over there but it seems like anything that cannot be fully automated goes into a doom spiral of low level customer support reps saying they will try to escalate and then nothing happening.

Evolution of the setup - personal laptop running separately w/ linked keyboard and mouse, ipad sidecar for terminal/calendar/todolist, poster board to not get distracted by people walking down the hall, logitech ergonomic keyboard and vertical mouse (saved my wrists)

FusOn-pLM is out in Nature Communications!!! 🎉 An INCREDIBLE effort (and a lot of sleepless nights! 🛏️) from my AMAZING 2nd year PhD student Sophia Vincoff and her team to train a new pLM that captures properties of some of the MOST disordered and pathogenic proteins known: fusion

I’m excited to share our significantly-updated preprint on de novo antibody design, where we now demonstrate the structurally accurate design of scFvs (in addition to VHHs) with RFdiffusion! biorxiv.org/content/10.110…

The true value of jupyter notebook for ML/data science is that it is a perfect debugging tool. Your project code should be structured in a way that makes it easy to copy paste/import large sections into a jupyter notebook for when you have to debug.