A high single dose of creatine can partially reverse metabolic alterations and cognitive deterioration associated with sleep deprivation. 🧵1/9

A link between yogurt intake and reduced risk of colon cancer, from cohort of over 130,00 participants, with inverse relationship to Bifidobacterium in gut microbiome tandfonline.com/doi/full/10.10… open-access

Massive congratulations to Alva Casey on her first author paper from her PhD: 'Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation' #immunometabolism

Last weeks #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Highlight: A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours.

Linoleic acid is the most abundant polyunsaturated fatty acid in the Western-style diet and has been implicated in promoting inflammation and cancer. In Science, researchers report a mechanism by which linoleic acid can activate the mTORC1 protein kinase, which coordinates

Now the supplement AG1 is in airport vending machines. At right is the complete list of peer-reviewed, independent research studies that show an improvement in health outcomes.

🚨Last weeks #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Highlight: Metabolic remodelling produces fumarate via the aspartate-argininosuccinate shunt in macrophages as an antiviral defence

I read this Cell paper that argues to have discovered a molecule (betaine) that mimics the geroprotective effects of exercise. This is a very valuable multi-omics resource, but the authors seemed to get caught in the rabbit hole of chasing a high-impact narrative🧵

Weight loss provides far more benefit than just losing fat nature Nature News & Views nature.com/articles/s4158… nature.com/articles/d4158…

Up to us…but also up to the bacterial, viral, parasite & other pathogens that repeatedly infect - and often persist - in our bodies across a lifetime. These pathogens can accelerate features of aging by hacking our gene expression, mitochondrial function & immune signaling

A review of the potential fo NAD+ supplementation which shows promise in animal experiments but: "Until these [clinical trial] results are available, definitive conclusions regarding the efficacy and long term safety of NAD+ boosting strategies remain premature."

📢Last 2 weeks of #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… biomed.news/bims-imicid/20… Highlight: Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism

I am pleased to mention that our AI-driven multi-omics ME/CFS paper is now freely available in full text on PubMed. All data have also been deposited on GitHub. pmc.ncbi.nlm.nih.gov/articles/PMC12…

📢Last weeks #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Highlights: Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.

More than 2 decades since GLP-1 drugs were introduced, we still don't know why people with diabetes lose about half as much weight as those without diabetes at the same dose nature.com/articles/s4136…

Very interesting article on myalgic encephalomyelitis/chronic fatigue syndrome and Long-COVID. #immunometabolism. Immunometabolism journals.lww.com/immunometaboli…

Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity medrxiv.org/content/10.110…

📢Last weeks #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… Highlight: Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion