De novo enzyme design!!! | Amazing work from Anna, Sam David Juergens and all the co-authors! Computational design of serine hydrolases biorxiv.org/content/10.110…

Congratulations, Luca! 🥳well deserved! 👍👍mpi-marburg.mpg.de/1430229/2024-0…

🚨 Job alert 🚨 Please retweet 🚨

I am pleased to share the peer-reviewed version of our manuscript on in vitro transcription-based biosensors and their application for in vitro pathway prototyping: doi.org/10.1093/synbio… Thanks to everyone involved in this work for great teamwork, support and guidance! SYBORG

Novel enzyme starts with promiscuity. Excited to share our study that shows how #evolution recruits a single enzyme for multiple purposes, showcasing the plasticity and flexibility of #metabolism. Huge thanks to my colleagues at SYBORG & Max Planck Institute for Terrestrial Microbiology! rdcu.be/dXaqU

How can `Sad` make E. coli happy? Through #evolution! Check out the latest study doi.org/10.1038/s41467… HaiHe and coworkers from SYBORG. #Synbio #Biocatalysis #Metabolism !

New in @EMBOjournal, we studied the evolution of essentiality in Form I Rubisco. While Georg Hochberg nicely summarizes the evolutionary implications of our work, let me summarize some of the cool biochemistry surrounding it. doi.org/10.1038/s44318… 🧵

Lets talk about #acetyl-CoA! As central molecule in C1 metabolism, the efficiency of its assimilation determines yields. Read below about our Lcm as novel activity in the shortest O2 tolerant route to make pyruvate from acetyl-CoA while fixing #CO2! nature.com/articles/s4146…

We designed a new route from acetyl-CoA to pyruvate. Helena Schulz-Mirbach provided a nicely written 🧵 below. Thanks for a great collaboration Helena Schulz-Mirbach, Ari Satanowski and SYBORG

Paper alert! 🎉 Excited to share this collaboration from my PhD time @wethebarevenlab and SYBORG! We built a new bridge in central metabolism, connecting acetyl-CoA and pyruvate via a novel, engineered pathway. For some personal highlights, come along 🧵 nature.com/articles/s4146…

Great highlight! Check it out

We are looking for a postdoc - in a project on a UbiD like (de)carboxylase!

Come join us in Marburg!

📢We invite candidates strongly interested in 𝗶𝗻𝘁𝗲𝗿𝗱𝗶𝘀𝗰𝗶𝗽𝗹𝗶𝗻𝗮𝗿𝘆 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗶𝗻 𝗺𝗼𝗱𝗲𝗿𝗻 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝘆 to apply for 𝗳𝘂𝗹𝗹𝘆-𝗳𝘂𝗻𝗱𝗲𝗱 𝗣𝗵𝗗 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀. Curious to learn more? See this 🧵 or visit imprs-marburg.mpg.de

Happy to share our story on evolution of protein quaternary structure! We discover an astounding variation in assembly across evolutionary timescales contrasted by strong functional conservation suggesting a significant role of non-adaptive processes nature.com/articles/s4146… 👇🧵

William Allen Neville Sanjana Rachel Yan Nature Biotechnology Bar-Even Lab Ari Satanowski Helena Schulz-Mirbach Philipp Wichmann SYBORG And a great thread from author Ari Satanowski! Thank you for choosing Twist genes to support this work! 🧬

Glad to see my main PhD project finally out Nature Microbiology nature.com/articles/s4156… We show for the first time that a synthetic and engineered pathway can indeed exceed nature at one-carbon fixation.

I'm truly excited to announce our new publication in nature unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to Anuj Kumar for the fantastic illustration! LINK: nature.com/articles/s4158…

Huge congratulations to Franziska Sendker! mpi-marburg.mpg.de/1511259/2025-0…

Huge congratulations to Maik Wolfram-Schauerte! mpi-marburg.mpg.de/1511202/2025-0…