Hakan Önder (@onder_haka2124) 's Twitter Profile
Hakan Önder

@onder_haka2124

Assoc.Prof. MD

ID: 1701695522925318145

calendar_today12-09-2023 20:33:45

619 Tweet

98 Followers

521 Following

Hakan Önder (@onder_haka2124) 's Twitter Profile Photo

TALAPRO-2: Talazoparib+Enzalutamide hits 45.1 mo OS (HR 0.62). A landmark result (Z=–3.58, SNR=3.58, p<2.6×10⁻⁹ [our calc]) But no survival analysis by prior mHSPC therapy despite its known prognostic impact. A critical blind spot. 📄 doi.org/10.1016/S0140-… #ProstatCa #PARPi

TALAPRO-2: Talazoparib+Enzalutamide hits 45.1 mo OS (HR 0.62). A landmark result (Z=–3.58, SNR=3.58, p&lt;2.6×10⁻⁹ [our calc])
But no survival analysis by prior mHSPC therapy despite its known prognostic impact. A critical blind spot.
📄 doi.org/10.1016/S0140-…
#ProstatCa #PARPi
Hakan Önder (@onder_haka2124) 's Twitter Profile Photo

🔹FLAURA2 confirms it: Osimertinib + chemo sets a new OS record (50.0 vs 42.1 mo, HR 0.75). But does this kill sequential strategy? Not necessarily. Post-progression Amivantamab still matters perhaps even more after earlier TKI + chemo pressure. 🔗 bit.ly/FLAURA2-OS #EGFR

🔹FLAURA2 confirms it: Osimertinib + chemo sets a new OS record (50.0 vs 42.1 mo, HR 0.75).
But does this kill sequential strategy?
Not necessarily. Post-progression Amivantamab still matters perhaps even more after earlier TKI + chemo pressure.

🔗 bit.ly/FLAURA2-OS
 #EGFR
Hakan Önder (@onder_haka2124) 's Twitter Profile Photo

🔬NEW in Lancet Oncology: HER2DX risk score independently predicts survival in early HER2+ breast cancer. Across 11 studies (n=2518), HER2DX stratified long term EFS beyond stage, pCR, or HR status. 📄 doi.org/10.1016/S1470-… #BreastCancer #Oncology #HER2

🔬NEW in Lancet Oncology: HER2DX risk score independently predicts survival in early HER2+ breast cancer.

Across 11 studies (n=2518), HER2DX stratified long term EFS beyond stage, pCR, or HR status.

📄 doi.org/10.1016/S1470-…
#BreastCancer #Oncology #HER2