TALAPRO-2: Talazoparib+Enzalutamide hits 45.1 mo OS (HR 0.62). A landmark result (Z=–3.58, SNR=3.58, p<2.6×10⁻⁹ [our calc])
But no survival analysis by prior mHSPC therapy despite its known prognostic impact. A critical blind spot.
📄 doi.org/10.1016/S0140-…
#ProstatCa #PARPi
🔹FLAURA2 confirms it: Osimertinib + chemo sets a new OS record (50.0 vs 42.1 mo, HR 0.75).
But does this kill sequential strategy?
Not necessarily. Post-progression Amivantamab still matters perhaps even more after earlier TKI + chemo pressure.
🔗 bit.ly/FLAURA2-OS
#EGFR
🔬NEW in Lancet Oncology: HER2DX risk score independently predicts survival in early HER2+ breast cancer.
Across 11 studies (n=2518), HER2DX stratified long term EFS beyond stage, pCR, or HR status.
📄 doi.org/10.1016/S1470-…
#BreastCancer #Oncology #HER2