We are organising a conference "Genomics in Ageing and Disease", 16th September 2024, University of Essex, Colchester. More details soon gate.essex.ac.uk

nucMACC: An MNase-seq pipeline to identify structurally altered nucleosomes in the genome science.org/doi/full/10.11… #FragileNucleosome github.com/uschwartz/nucM…

Registration (free!) and abstract submission now open! Please, spread the word. gate.essex.ac.uk

Determining mesoscale chromatin structure parameters from spatially correlated cleavage data using a coarse-grained oligonucleosome model dlvr.it/TBDHZZ

We have an opening for a three-year postdoctoral position for a researcher with expertise in machine learning and genome bioinformatics, to work on cancer diagnostics (liquid biopsies). Please apply here: vacancies.essex.ac.uk/tlive_webrecru…

1/ 🤔 Do #chromatinlooping-mediated promoter-#enhancer interactions drive gene expression? Or is the local enrichment of transcription factors into hubs/#condensates the key factor? Our AC/DC model of gene regulation at bioRxiv doi.org/10.1101/2024.0… provides a new view on this.

FACT-(H3-H4) complex stimulates Pol activity to coordinate DNA synthesis with nucleosome assembly dlvr.it/TBhRty

Impacts of nucleosome positioning elements and pre-assembled chromatin states on expression and retention of transgenes dlvr.it/TCCv4G

The registration deadline for our FREE conference in Colchester is prolonged until 1st September. The conference itself is on 16th September. Short talk slots available, hurry up!

Single-nucleosome imaging reveals principles of transient multiscale chromatin unfolding triggered by histone ADP-ribosylation at DNA lesions dlvr.it/TCZn9R

Hurry up! Last day to submit abstract for "Genomics in Ageing and Disease" (Colchester, 16th September). Free Registration! Talks by @Peter_Fraser1, Aimée Parker, Gabi Ficz, Anton Enright, Raheleh Rahbari, Ozgen Deniz, Jordana Bell, Sarah Marzi & Essex PIs gate.essex.ac.uk

DNA flexibility regulates transcription factor binding to nucleosomes dlvr.it/TCkpV0

CTCF binding landscape is established by the epigenetic status of the nucleosome, well-positioned relative to CTCF motif orientation biorxiv.org/content/10.110…

Our new CTCF breakthrough ms has been posted today at doi.org/10.1101/2024.0… with the following Graphical Abstract:

Chromatin Buffers Torsional Stress During Transcription biorxiv.org/content/10.110… [Jin Qian, Lucyna Lubkowska, Shuming Zhang, Chuang Tan, Yifeng Hong, Robert Fulbright, James Inman, Taryn Kay, Joshua Jeong, Deanna Gotte, James Berger, Mikhail Kashlev, Michelle Wang]

1/n Looking into history of "fragile nucleosomes". The term was introduced in Xi et al, 2011 genome.cshlp.org/content/21/5/7……. But before that, MNase-sensitive nucleosomes were known as "labile nucleosomes", since 1970s academic.oup.com/nar/article/6/…. This term then continued into the NGS era

Acute multi-level response to defective de novo chromatin assembly in S-phase (Dreyer et al., 2024) cell.com/molecular-cell…

Chromatin architecture mapping by multiplex proximity tagging [Delamarre et al. 2024] biorxiv.org/content/10.110… ▶️Nucleosome maps in 3D with Proximity Copy Paste (PCP) ▶️Connectivity of nucleosomes in S. cerevisiae ▶️Chromatin is predominantly organized in regular nucleosome arrays

Nucleosome condensate and linker DNA alter chromatin folding pathways and rates [Qiu et al, 2024] biorxiv.org/content/10.110… ▶️residue-level coarse-grained models; non-Markovian dynamics ▶️10n bp DNA linker lengths favor zigzag fibrils ▶️10n+5 bp chromatin loses unique conformations

We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more jobs.ac.uk/job/DMK060/sen…. Apply by 21st April 2025!