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Another step forward in sp³-rich medicinal chemistry! 🚀 Excited to share: the NMR data for our 1-methyl-2-oxabicyclo[3.1.1]heptan-4-amine looks beautiful! Clear signals — ready for next steps in bioisostere design! 🛒 Find this Building Block at the EnamineStore #nmr #nmrchat

A comment on the last challenge☝️: as you can see from the picture, a neighboring acetyl group can strongly affect the chemical shift of the phenolic OH proton (9.7 vs 11.8 ppm). The reason is the formation of an intramolecular hydrogen bond. 👌 #nmr #nmrchat #chemistry l