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Researchers alongside Dr. Eric Nestler from Friedman Brain Institute show that vHipp dopamine dynamics gate exploratory behaviors under contextual uncertainty. 🧠 📚 Read more in nature: go.nature.com/3Z7wHjn

Scientists discuss the role of kinase–kinase networks in the pathogenesis of #neurodegenerative diseases and illustrate the advances of clinical applications of protein kinase inhibitors for early intervention. 📖 🌞 Enjoy reading the review: go.nature.com/4k9MWEy

Dr. Zachary Freyberg's team discovered key sex and regional differences in mitochondrial generation of cytotoxic ROS and their implications for dopiminergic neuron resilience using the Drosophila model. 🪰 Aging Cell | bit.ly/4dhvE6j

Dr. Jay Baraban's team investigated the effect of deleting the translin/trax microRNA-degrading enzyme on cocaine-induced behavioral responses in mice. 🐭 Read their findings: go.nature.com/3F7WxNq

Fresh off nature! The Debby Silver at Duke University School of Medicine uncovered new functions of HARs as key regulatory elements crucial for the expansion and complexity of the human cerebral cortex. 🧠 go.nature.com/4j125qY

🧪 Researchers led by Drs. Alex Chen & Misha Ahrens found that norepinephrine (NE) modulates larval zebrasfish behavior through astroglial release of ATP, extracellular conversion of ATP into adenosine, and neuronal adenosine receptor activation. bit.ly/4jXjhPn

The Thomas Papouin (Papouin Lab - WashU) members led by Katheryn Lefton showed that, in mice, norepinehprine modulates synaptic function through a signaling pathway involving astrocytic adrenergic receptors. 🐁 More in Science Magazine: bit.ly/43xL1Er

Drs. Kevin Guttenplan, Marc Freeman, and team at Vollum Institute established a mechanism by which #astrocytes dynamically respond to and modulate neuronal activity in different brain regions and in different behavioral states. Science Magazine | bit.ly/3ZiVBg0

Hanyang University researchers suggest that NIMA-related kinase 1 contributes to #ALS pathogenesis through the loss-of-function mechanism. 🔬 Get the full details of their study: bit.ly/45hMzUi

How does the brain fuel itself? Scientists have created the first-ever map of mitochondria across the entire human brain. This groundbreaking achievement brings us closer to understanding age-related brain disorders and beyond. 🤯 go.nature.com/3YQE9iG

📢 Check out this new nature study! .Fran Quintana Lab and collaborators establish that IL-11–STAT3-driven #astrocytes suppress #glioblastoma-specific protective immunity by inducing TRAIL-dependent T cell apoptosis. 👉 go.nature.com/3F3NyNt

.Mount Sinai Health System is seeking an Associate Director of the #BrainBodyResearchInstitute w/ additional appointments in the Nash Family Department of Neuroscience, Friedman Brain Institute, Lipschultz Precision Immunology Institute & relevant clinical depts Icahn School of Medicine at Mount Sinai. Learn More➡️neuroscience.mssm.edu/pdf/Brain-Body…

Drs. Joris De Wit (Lab of Synapse Biology) and Ben Verpoort identified a postsynaptic signaling complex comprising the G protein-coupled receptor- GPR158 and PLC X-domain containing 2, that controls spine apparatus abundance. 💡 Learn more: bit.ly/4jkjsDt

Drs. Zhongcong Xie & Guang Yang collaborated on this study highlighting the critical role of the astrocytic PERK-CK2-AQP4 axis in glymphatic dysfunction and #AlzheimersDisease pathogenesis. Neuron | bit.ly/45mS7Nk

Scientists demonstrate that GSK-3β overexpression in GABAergic interneurons compromises adult hippocampal #neurogenesis and promotes NSC apoptosis via disruption of GABAergic signaling. 🧠 More in Aging Cell: onlinelibrary.wiley.com/doi/10.1111/ac…

.Northwestern Feinberg School of Medicine researchers, Drs. Katherine Sadleir & Robert Vassar, led this study showing a role of annexin A6 in reducing dystrophic neurites in the 5XFAD #amyloid mouse model. 🐁 ✅ Check out their study! bit.ly/4khzrDw

Dr. Maria Lehtinen's team shows that the activation of serotonergic 5-HT2C receptors triggers sustained Ca2+ signaling, driving high-volume apocrine secretion in mouse and human #ChoroidPlexus. 🧠 ✅ Check out their study in Nature Neuroscience: go.nature.com/45yqVvd

Antonio Falasconi, Harsh Kanodia, & Silvia Arber demonstrate the existence and function of highly specific and temporally precise movement representations in basal ganglia output circuitry. Biozentrum, University of Basel 🖨️ Now in nature: go.nature.com/4524heE

Amanda McQuade (Amanda McQuade) uses iPSC-derived #microglia to understand genetic risk factors for #AlzheimersDisease. The cells play a role in activating #neuroimmune responses to pathological aggregates. Learn more in STEMCELL Technologies's on-demand webinar!

This PLOS Biology study highlights the crucial function of the m5C reader protein Ybx1 in promoting cell cycle progression of the embryonic cortical progenitors, essential for proper cortical development. 🧠 📖 Full story: bit.ly/3Su1uU4