The retrieval and dominance of aversive memory retrieval, relies on specific changes in activity and connectivity at parvalbumin inhibitory synapses onto aIC pyramidal neurons projecting to the basolateral amygdala.biorxiv.org/content/10.110…

So this is now officially out! Our studies Rosenblum Lab demonstrate how interactions between defined inhibitory and excitatory cortical neurons undelie the coherency of aversive memory retrieval - an evolutionary pre-requisite for animal survival. sciencedirect.com/science/articl…

We patched the dendrites of PV+ basket cells in the hippocampus and found that sub-linear integration dramatically enhances neural synchrony during gamma oscillations. Finally out after 5 years in development. biorxiv.org/content/10.110…

Interesting new review on the role of interneurons in sleep and memory processes MCDB Michigan frontiersin.org/articles/10.33…

Quinone reductase-2 mediated intrinsic property changes of SST interneurons in the aIC is a central removable factor to allow novel taste memory formation. Rosenblum Lab eneuro.org/content/early/…

Online now! Brain-wide neuronal imaging of C. elegans shows that correlations of activity between functionally unique neurons are not fixed, but depend on behavioral context #neuroscience bit.ly/3CCMclV

Ten years and two countries later, my PhD research at the University of Dundee is now published Molecular Metabolism ! #metabolism #inflammation #cytokines #insulin sciencedirect.com/science/articl…

Using retrograde viral tracing, behavioral analysis, and electrophysiology at the insular cortex, we reveal that the intrinsic properties of BLA-projecting neurons are regulated by innate and learned drives, as a function of certainty of taste valence prediction, but not percept.

Grateful to for the opportunity and proud to be part of the development of @Synendos. Brief communication on the endocannabinoid Odyssey to the Ithaca of drug development nccr-transcure.ch/communication/…

🔓#OA Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion ➡️doi.org/10.1016/j.molm… UoD Medicine Alison McNeilly Adonis Yiannakas J Gallagher Jamie Tarlton Prof M Ashford, Prof R McCrimmon #Interleukin6 #FoodIntake #EnergyExpenditure #InsulinSecretion

Looks like ethanol-driven taste aversion memories also rely on parvalbumin inhibition on insular cortex neurons projecting to the amygdala. biorxiv.org/content/10.110…

New insights into insular interhemispheric circuits! 🧠 Neurons, crucial for social behavior, become hyper-excitable after 24h of social isolation in male mice. These unmyelinated neurons connect with the CeA and BNST, playing a key role in social behavior ncbi.nlm.nih.gov/pmc/articles/P…

Last week's new beginnings at EUC Medical School in Frankfurt EUC

Thrilled to share our latest research on intra-insular circuits and their role in immune regulation and memory! We reveal how brain circuits encode immune memories, offering new insights into neuroimmune communication and how the brain can shape immunity. nature.com/articles/s4159…

Our latest research on ERK1/2 nuclear translocation in extinction learning is now published! We used viral-mediated peptide delivery to block nuclear ERK1/2 selectively. ERK1/2 nuclear translocation is critical for memory extinction. RosenblumLab molecularbrain.biomedcentral.com/articles/10.11…

🎊Check out our latest publication "Exploring Simple Drug Scaffolds from the Generated Database Chemical Space Reveals a Chiral Bicyclic Azepane with Potent Neuropharmacology" in Journal of the Medicinal Chemistry! Read the full version here👉pubs.acs.org/doi/10.1021/ac… DCBPunibern

A novel open-source system enables hi-res microstructure analysis of licking in mice • Dissociates innate vs. learned aversion • Beyond cumulative consumption assays • Reveals unique signatures for appetitive, aversive & neutral tastants Rosenblum Lab frontiersin.org/journals/syste…

Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation in Autism nature.com/articles/srep3…

NAMPT, a key component of the NAD+ pathway seems to be a highly promising target for brain cancer. reliawire.com/nampt-survival…

The #neurogrid and the quest of mapping brain learning circuits. nature.com.proxy.readcube.com/nm/journal/v23…