Kai Wang and his team at the Institute of Neuroscience in Shanghai developed a variant of structured illumination microscopy called MLS-SIM that allows super-resolution imaging of neuronal structures such as spinules, spines and boutons in awake mice. nature.com/articles/s4159…

Human cortical pyramidal neurons are larger, exhibit more complex branching patterns, and feature distinctly nonlinear biophysical properties compared to rat cortical pyramidal neurons. Do these unique characteristics make human neurons more functionally complex? Would that

🧠 Built an open-source SWC neuron morphology editor! Visualize and edit neuronal structures in 2D, with easy import/export functionality. Perfect for pre-processing morphologies before NEURON simulations. Try it out: deangeckt.github.io/swc_editor/ #neuroscience #opensource

Branch-specific spike failures at distal axons in mouse cortex in vivo #ISFN

Neuroscience Unleashed in Jerusalem July 20–24 2025 An international graduate school on consciousness, NeuroAI, brain-machine interfaces, psychedelics & organoids. Graduate students & postdocs: Apply by April 19 2025 iias.huji.ac.il/29LifeSci RT to help spread the word 🙏

Will be interesting to hear Christof Koch on "Beyond physicalism - consciousness, quantum mechanics, and mystical experiences."

Super happy that our papers #2 and #3 from our 3-person lab just went online on bioRxiv! First large-scale 3DEM dataset from mouse hippocampus CA1 biorxiv.org/content/10.110… check out the beautiful data on webknossos wklink.org/7023! ...

Our work elaborating on, simplifying, and extending earlier formulations of the dynamics of calcium-based plasticity has been published in JOCN. Bottom line is 'calcium tells the synaptic weight where it's going and how fast it gets there.' Link in comment.

Honoring Ethel Browne, pioneer developmental biologist who discovered induction in Hydra but was never recognized: blogs.cuit.columbia.edu/rmy5/ethel-bro…

Today, in collaboration w/ colleagues at the Institute of Science and Technology Austria (ISTA), we report the first-ever method for using light microscopy to comprehensively map all the neurons & their connections in a block of mouse brain tissue. More →goo.gle/4maUNUs

Join Us for Hands-On Tutorials and Demos at CNS*2025! OCNS 📅  Saturday, July 5, 2025 ⏰  09:00 - 16:00 CEST 📍  Firenze Fiera - Room 4 Full day of interactive sessions, live demos, and guided tutorials showcasing the Open Brain Platform Program: cns2025florence.sched.com/event/25kRZ/ex…

Whole-brain reconstruction of the mouse at 1-μm resolution. Axonal branching is mapped in detail. nature.com/articles/s4158…

On July 5 at the CNS*2025 tutorial session in Florence, I'll present our work on simulating fully EM-reconstructed cortical neurons with the new Open Brain Institute platform. Join us to explore and accelerate progress in computational neuroscience! OCNS Idan Segev Lida Kanari

Our neighboring lab just posted an exciting new bioRxiv preprint investigating social behavior in zebrafish through whole‑brain activity recordings.

Nanoscale dendritic shaft constrictions shape synaptic integration in fine caliber principal neuron dendrites biorxiv.org/content/10.110… #biorxiv_neursci

Dendrites have been under the microscope, since 1888. We took it further and put dendrites under 3 different microscopes (ExM, STED, EM) and reconstructed entire branches to reveal fine nanoscale details. #SuperResolution #ElectronMicroscopy #Morphology doi.org/10.1101/2025.0…

It’s always a great read when scientists introduce a new concept. Here the authors claim that dendrites are not continuous tubes but have dendritic shaft constrictions, suggesting that there could be compartmentalization within dendrites biorxiv.org/content/10.110…

Dynamics of Excitability in Axonal Trees biorxiv.org/content/10.110… #biorxiv_neursci

What makes human pyramidal neurons uniquely suited for complex information processing? How can human neurons’ distinct properties contribute to our advanced cognitive abilities?

Annoucing next online Dendritic Integration symposium December 11th, 2025 Columbia University Neurotechnology Center. Online, free registration, great speakers! ntc.columbia.edu/dendritic-inte…