New! Online now: The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening dlvr.it/T93wtN

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening Cell Metabolism cell.com/cell-metabolis…

ARMI researchers have contributed to a new paper, published in Cell Metabolism, demonstrating a mechanistic connection between aging and development. Congratulations to all the authors! More below 👇

Excited to share our latest work in Cell Metabolism and lead by NefzgerLab 🦋 @nefzgerlab.bsky.social Ralph Patrick and myself Marina Naval uncovering a common transcription factor pattern linked to organismal maturation and ageing. Interested? Read the thread below!

Huge congrats to NefzgerLab 🦋 @nefzgerlab.bsky.social and his team at Institute for Molecular Bioscience on this epic paper that identifies fundamental molecular patterns that drive #ageing across cell types and species. An incredible effort co-ordinating huge sets of collabs, cells, data. Great to work with you bud👏👏👏

Researchers have unlocked crucial molecular secrets of ageing in cells, potentially paving the way to improve quality of life as people age. Cell Metabolism, NefzgerLab 🦋 @nefzgerlab.bsky.social, Marina Naval, Ralph Patrick 🔗 bit.ly/3xPDOmk

Master controller of aging and development uncovered New insights into transcription factors and chromatin remodeling reveal potential for improving age-related health outcomes. #innovation #aging longevity.technology/news/master-co…

🤔 Interesting recent result connecting development and aging: “AP-1 … progressively activated adult genes, whilst the activity of ‘early-life’ genes involved in development were dialled down, and this process was shared across cell types.” uq.edu.au/news/article/2…

Very cool multi-omic analysis of development and aging across >45 mouse and human cell types. They find a transcription factor binding site signature common to aging and development and propose that activator protein 1 (AP-1) drives maturation and is later hijacked in aging.

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening sciencedirect.com/science/articl…

🙏 to Manuel Serrano for writing a preview 👉 doi.org/10.1016/j.cmet… for our study NOW IN PRINT Cell Metabolism. We introduce the "Stimulus-Induced Programming Hijacks Ontogeny" (SIPHON) model for chromatin & transcriptome remodeling in organismal maturation & aging We provide

A pattern emerges in chromatin aging: AP-1 steals the show dlvr.it/TBvzgR

A pattern emerges in chromatin aging: AP-1 steals the show cell.com/cell-metabolis…

Say whaaat!?? 👇👇👇ever wanted to visit Australia & see great science?? ‘We are excited to announce that the next Hunter Meeting will take place June 2nd-5th 2025 at the Rydges Resort, Hunter Valley’ Hunter Meeting It’s worth the long haul flight, I promise.