Wassup y’all, my first manuscript from the Aoto Lab is out! Despite being discovered over 30 years ago, α-Nrxn influence on synapses remain enigmatic. Here, we investigate how different mutations in Nrx3α affects synaptic properties. Check out this study— jneurosci.org/content/44/41/…

💥💥💥New preprint 💥💥💥on the EuPRI resource. Where we reconstruct the motifs for 34,736 RBPs and study their function and evolution. Joint work with Tim Hughes (Toronto), Matt Weirauch, @LXandR_, Deb Ray, Kaitlin Laverty and many more. More details to come

The impact of cell states on heterochromatin dynamics pubmed.ncbi.nlm.nih.gov/39422321/

Elsevier is one of the largest, most hated and most influential academic publishing companies in the world. How it started & how it's going A thread🧵

Congratulations to Denethi Wijegunawardana, a Yale Interdepartmental Neuroscience Program student & @YaleRNA Steitz Fellow in the lab, for publishing her postbac work from Pallavi Gopal's lab Yale Pathology on TDP-43 & Ataxin-2 RNP granules in Developmental Cell! Yale Neuroscience Yale Kavli Institute for Neuroscience @YaleRNA sciencedirect.com/science/articl…

Timescales in Cell Biology

New lab 📰 in Nucleic Acids Res, the 2nd paper of star postdoc Sveta Farberov. A tour-de-force into how we can use MPRAs to understand binding-function landscape for RBPs. We address the following Qs: academic.oup.com/nar/advance-ar…

In this Review, La Fleur et al. dive into the world of massively parallel reporter assays (MPRAs) in studying RNA and gene regulation. Yongsheng Shi Georg Seelig Learn more about the power of MPRAs in therapeutic design when coupled with machine learning: ➡️ tinyurl.com/gd351800

Another opportunity to join the faculty at Vanderbilt University! Deadline is less than 1 week away!

The Molecular Biology PhD program is well represented at SACNAS #2024NDiSTEM! If you are interested in our program, please visit booth 1257 from the Anschutz Campus Graduate School, scan your code for an application fee waiver, and pick up a flyer

happy election day

Achievement unlocked: 2 papers in the same issue of Cell Stem Cell, one on the cover with Pluchino lab - Regenerative Neuroimmunology and another great one with Eric Pietras lab. Grateful for the opportunity to learn from great colleagues on a daily basis! cell.com/cell-stem-cell… cell.com/cell-stem-cell…

Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. biorxiv.org/cgi/content/sh…

THE OINC IS HERE! New tour-de-force with Matthew Taliaferro, years in the making! Direct sequencing of chemical modifications on RNA to measure RNA localization transcriptome-wide. Read about OINC-seq here: biorxiv.org/content/10.110…

We are up! also a 'featured article' on their homepage science.org/journal/stm CONGRATS to all co-authors! Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis | Science Translational Medicine science.org/doi/10.1126/sc…

I’m thrilled to share this story from Joshua Mendell and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…

Happy to see it out and to be part of this fantastic work 🥳 Check out the story on CDS m6A-mediated RNA decay (CMD)!

Don't miss out on our winter promotion. All 6 rxn riboPOOL kits for 49 €! Request a quote here: buff.ly/3Cf5x1n . *Promotion valid until Feb. 28th.🧡 #rRNAremovalkit #RNASeq

“I QUIT FOOTBALL” Dave Portnoy is sick of the refs giving the Chiefs every inch

I think this depressed Bills fan speaks for all of Buffalo. I feel for #BillsMafia @theshredline