Happy to share the final version of our paper, showing how essential invasion machinery is deployed by our most deadly malaria parasite to burrow its way into our red blood cells. Proud of the team! Thanks to @Wellcome for funding to make it possible. nature.com/articles/s4158…

If you want to discover more about our recent @nature paper on red blood cell invasion in malaria, check out this video. Brendan Farrell Nawsad Alam and Melissa Hart, who led this work, tell you all about it! youtube.com/watch?v=gOMMK4…

"A true mentor is someone who has more imagination about you than you have about yourself" nejm.org/doi/10.1056/NE…

Excited to unveil this study aimed at deepening our comprehension of epitope-focused vaccines targeting blood-stage malaria... #malaria #vaccines

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…

Presenting this work malaria blood stage vaccine design and interacting with other attendees was a great experience. EMBL Events #EMBLMalaria #BioMalPar2024

Just out Nature Immunology A single infusion of engineered T cells put asthma in long term remission in the mouse model nature.com/articles/s4159…

#MeetTheResearcher Introducing Nawsad Alam from Professor Matt Higgins' lab. As a postdoctoral researcher, Nawsad uses structure-guided approaches to design effective blood-stage #malaria vaccine candidates.

Scotland has detected no cases of cervical cancer in women born between 1988-1996 who were fully vaccinated against HPV between the ages of 12 and 13. statnews.com/2024/01/25/hpv…

Thanks Trends in Parasitology for highlighting our structure-guided design of PfRH5-based vaccines. In particular, PfRH5.2 which combines truncations from Wright et al (2014) and mutations from Campeotto et al (2017). Good to see it outperforming PfRH5.1! cell.com/trends/parasit…

One of my favourite proteins! It’s fantastic to see how structure-guided approaches are producing such impressive results!

The capability for producing "mirror life" is out there and poses danger. When some scientists who worked on this became aware, they stopped pursuing it, and co-authored this piece, along with over 30 leading scientists—a Science Magazine policy forum that lays out the risks

Read all about it in our preprint: biorxiv.org/content/10.110…

An incredible chance to be part of impactful work!

Another job available in our team! We are seeking a project manager to help us to manage our malaria vaccine development projects. See here: my.corehr.com/pls/uoxrecruit…

It was great to share my work on designing RH5top - really appreciated the engagement. Huge thanks to the organizers for the opportunity!

Looking for a fully-funded D. Phil. / Ph.D. studentship in structural biology and vaccinology? Come to join our team. Fully and generously funded by a donation from the Kyner-Field family with full fees at overseas level. Join us?? bioch.ox.ac.uk/studentships

Our latest story describes the amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind inhibitory KIR receptors and suppress immune cell function while humans have activating KIR receptors to bind these RIFINs to kill parasites!

Delighted to share the final version of Richard Zhou's study on how the CD163 scavenger receptor cleans up after toxic haemoglobin spills out from our blood cells. An amazing grabber mechanism! rdcu.be/ewPA2

Delighted to share our review on how those malaria parasites get into our blood cells and how we might stop them. rdcu.be/eGnUl