i’ve always been puzzled as to the mechanism that might explain why glucose drives aspects of aging. This paper shows a totally new way in which glucose exerts biology. Could elevated glucose be driving pathological cell fate decisions?

Molecular dynamics simulations in mixed reality! With Luciano Abriata and Lucien Krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies. Stay tuned, lots of cool stuff coming soon! Three.js #WebXR #Quest3

🧬What are protein language models (PLMs) actually learning about biology? Our paper introduces InterPLM - a framework that reveals interpretable features in PLMs using sparse autoencoders, giving us a window into how these models represent protein structure and function. 🧵(1/9)

so 2 guys named Ned walk into a bar . . . statnews.com/2024/11/19/jup…

so then the bartender asks…. the regular? endpts.com/jupiter-bioven…

yay, bruce! Bruce Booth

Bruce Booth Matthew Herper STAT A missed opportunity to name this D.O.S.E. (Department Of Startup Efficiency). 🐕 Good luck to Norman Sharpless and Nathaniel David!

brawhaha. DOSE!!! Anirban Maitra Bruce Booth Matthew Herper

GDF15 positioned as a dynamic biomarker of psychosocial stress accessible in human blood and saliva, pointing towards a shared psychobiological pathway linking mental and mitochondrial energetic stress. biorxiv.org/content/10.110…

You can check out your foxo3 status using your 23&me raw data.

have to do it manually now alas

This is what the internet was made for

2024's top 10 advances in medicine (🧵) 1. The numerous benefits of GLP1R agonists As well as causing weight loss, GLP1s can prevent complications of obesity (diabetes, liver fibrosis, kidney disease, osteoarthritis), treat heart failure, and even slow down Parkinson's:

In my 40 years of biotech, I was waiting to see this result. Never before have transplanted cells survived normal immune response without immunosuppression. Excited for patients, many whom I know see hope today for a possible cure for many diseases. globenewswire.com/news-release/2…

cool

CAR T cells have shown efficacy in blood cancers and autoimmune disease. In my lab’s recent preprint, we developed CAR Tregs to tackle the #1 cause of human mortality - heart disease. biorxiv.org/content/10.110…

This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:

our educational system is extremely unfun. you're forced in a classroom metabolizing lifespan for 8 hours a day, cramming homework, memorizing lists... we want creative project-based learning. 1:1 tutoring. personalized, self-paced lesson plans. joy and mastery drive discipline!

cool result. turns out you need the right sugar coating on your blood vessels as your age to keep them from leaking into your brain.

Naked mole-rats pulled a cosmic prank on biology: by swapping four amino acids in cGAS, they flipped a gene that normally summons the apocalypse into one that repairs the genome. pubmed.ncbi.nlm.nih.gov/41066557/