A huge congratulations to our ASM Nancy Millis Student #award winners! Each presenter won their respective state's competition and these talks were truly superb. Well deserved!! #ASM2023

Our paper on the carbapenem resistance mechanisms in a clinical strain of Klebsiella is finally out in eLife :) Well done to all co-authors - including Natalia C. Rosas PhD, Jonathan Wilksch, Michael J. McDonald & trevor-lithgow.bsky.social! Link and quick summary below. elifesciences.org/articles/83107

We find this specific strain carries no carbapenemase-encoding genes. Here, carbapenem resistance evolved from previous selection for ceftazidime resistance, with added potentiating evolution via ompK36 porin mutations.

However, the genetic loci that confer resistance are extremely costly to fitness, and sensitivity to carbapenems is rapidly restored in the absence of drug selection during evolution experiments.

This research has wide clinical implications, suggesting that combination therapy with ESBL inhibitors would be effective, and cautioning against phage therapy that utilises ompK channels for action against CRE.

Centre to Impact AMR Monash University

Dr Srijan Jindal highlights the actions that individuals must take to stop the development of AMR, save antibiotics and also the lives of millions of people.|... youtu.be/UTBwSJZ6H3g via YouTube #AMR

Proud to announce our Indo-Pacific Future Leaders in AMR HDR student forum. It complements our mission to strengthen & grow a regional network of next-generation leaders to fight #AMR. A creative think tank supporting new members & visiting students. monash.edu/impact-amr/ind…

Excited to share our latest and my first, first author paper in mBio! The lesser studied short chain fatty acid crotonate reduces invasive growth and immune escape of Candida albicans by regulating hyphal gene expression. Traven Lab Monash Biomedicine Discovery Institute journals.asm.org/doi/10.1128/mb…

A wonderful time sharing lunch with the now much larger LithgowLab 🌞 trevor-lithgow.bsky.social

Discover the ground-breaking applications of phage therapy to combat antibiotic resistance on SBS Australia featuring Centre to Impact AMR’s A/Pof Jeremy J Barr and PhD Alum Dr Fer—where the sky is blue—nando from School of Biological Sciences, Monash and Prof Anton Peleg from Monash Biomedicine Discovery Institute on Thurs 15 Feb 📺💊: ow.ly/iULY50Qz1MN

Radio, televisión y periódicos. Promocionar el documental Last Chance to Save a Life me ha hecho vivir mi mejor vida de artista 🤩 Estreno este Jueves ❤️