Please RT! My lab is recruiting a Specialist to join us on several exciting new projects related to T cells in MS and novel therapeutic targets. Ideal applicants should have flow cytometry experience. Apply here: aprecruit.ucsf.edu/JPF05166

Summer lab photo! Jared Vega Goodman Next time you won't have to take the pic

Soluble NCAM-1 and VCAM-1 as potential biomarkers for cognitive decline in inactive primary progressive MS. #CognitionDecline #MultipleSclerosis #PPMS #Biomarkers #Onestepforward #CarloscamaralemarroyLab

Incredibly excited to announce that the program will be growing. For 2025, we will be matching 13 applicants (From 11) to a categorical WashU Medicine Neurology PGY-1 position. Ultimately, the program will expand from 44 to 52 residents! NRMP® #match2025 #neurotwitter #MedTwitter

Attending #ASCP2024? Be sure to stop by our booth and say hello to Nikki!

Incredibly excited to share our latest work exploring the antigen specificity of clonally-expanded CSF-enriched CD8+ T cells in MS  #multiplesclerosis #Tcells #EBV 🧵1/ biorxiv.org/content/10.110…

Excessive and repetitive Ampicillin treatment alter the gut-brain axis. Ampicillin induce neuroinflammation through NfL, NOS2 and GFP release. Check out 👇 the work by @TouilBoukoffa team. jni-journal.com/article/S0165-…

Gregory Wu Kate Sadler Another super important TRP paper that I just came across because of a new paper on how fever impacts CD4 T cell responses by Darren Heintzman. Linking the TRPV paper here to add it to this thread: pubmed.ncbi.nlm.nih.gov/32839313/?s=08

Post-mortem MS brain display PD1+ Granzyme B+ tissue-resident memory (Trm) T cells in MS lesions, in contact with EBV infected B cells promoting local CNS inflammation. Check out👇 this 2023 interesting study from Frenci sciencedirect.com/science/articl…

I'm excited to announce that Jennifer Lawrence's thesis work is now out! Check it out here: JCI Insight - Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown insight.jci.org/articles/view/…

Using sc-RNA-Seq to delineate T cell changes in AD, demonstrates an up regulation of exhaustion markers in CD8+ T RM cells within 5xFAD mouse brain. Check the link below 👇 jni-journal.com/article/S0165-…

Exciting news! Our new paper is published at Annals of Neurology! Check it out to see how large-scale CSF and blood flow cytometry can reveal disease clusters to improve diagnosis and understanding doi.org/10.1002/ana.27…

Gerd Meyer zu Hörste I am proud to share our manuscript published in ANA Journals today. 🥳doi.org/10.1002/ana.27… We used data-driven approaches to analyze paired #CSF and blood #FlowCytometry of 8,790 (discovery) + 3,201 (validation) patients. A #tweetorial 🧵1/16

So proud of this collaborative work! Thanks to all involved, including Claudia Cantoni Brian Edelson Maxim Artyomov Gerd Meyer zu Hörste Joe Sabatino

Happy to share this collaborative work looking at long term results of a high efficacy DMT in early #MS #ocrelizumab ⁦OMRF⁩ ⁦⁦Aaron Boster MD⁩ ⁦Barry Singer MD 🧠⁩ ⁦Dr. Brandon Beaber⁩ ⁦MS Views and News⁩ neurology.org/doi/10.1212/WN…

Pleased to write this editorial with Larry Steinman about a potential novel antibody in MS neurology.org/doi/10.1212/NX… Original manuscript here: neurology.org/doi/10.1212/NX…

Murphy Lab Bay #2: proving that science and chaotic shenanigans can coexist. 🙌 Sunny Kim

CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling Check out the paper below 👇 jni-journal.com/article/S0165-…

🚨 Paradigm shift in #MultipleSclerosis 🚨 New study in Nature Medicine shows MS is not fixed subtypes but a dynamic continuum of states across 4 dimensions: disability, brain damage, relapses & silent inflammation. 📖 Read: nature.com/articles/s4159… #MS #Neurology #AI