🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

We are looking forward to seeing Sergiu P. Pasca work. Please be aware that it is 1 pm (not 2 pm) at Lecture Theatre 1

Join us For Sergiu P. Pasca seminar TODAY from 13:00 - 14:00!

🚨 Deadline is approaching fast— 25th Sept! ⏳ There’s still time to get your application in and join us... 📄✨

To continue our External Seminar series, this week we welcome Dr Manual Valiente Manuel Valiente 🗓️ 1pm, Thursday 26 September 2024 📍 Lecture Theatre 2, New Hunt’s House, Guy’s Campus #metastasis #tumour #brain #neuroscience CNDD| King's College @cniostopcancer @renacer_brainmetnetwork

Registration now open for our next symposium! 🧠 From Discovery to Translation: Bridging the Gap in Neurodevelopmental Conditions 📅 18-19 Nov 2024 Organised by Jonathan O'Muir... Joel Winston Laura Pellegrini Alice Egerton & Laura Mantoan Tickets limited! shorturl.at/uTnPX

Fully funded iCASE PhD with Laura Pellegrini and The Vernon Lab to investigate psychedelic drug exposure in human choroid plexus & CSF using organoids. Apply by 29 Oct: lnkd.in/ePThisws #MRCDTP25 #PhDOpportunity #Neuroscience #MentalHealthResearch #Organoids #Psychedelics

Last few tickets remaining!

Please come along to our next External Seminar, this Thursday at 1pm. We will hear from @EBaBlab University of Bristol, hosted by DarrenWilliamsLab See you there!

Exciting and stimulating couple of days discussing how to bridge the gap in neurodevelopmental conditions. Huge thanks to all our speakers, organisers, and everyone who attended. #D2T24

We invite you to our inaugural lecture for Professor Robert Hindges called 'With an eye on the brain' 📅When? 3 December 2024 17.30-18.30 📍Where? Lecture Theatre 1, New Hunt's House, Guy's Campus Register at this link: kcl.ac.uk/events/profess… #Neuroscience

Apply now! Fully Medical Research Council funded #PhD fellowships with enhanced stipend in #neuroscience #neurodevelopmental disorders, CNDD| King's College. Deadline Jan 1st 2025! devneuro.org/cndd/phd-fello… Home students only I'm afraid. Please RT!

1/10 Our latest research, led by Martijn Selten, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story nature nature.com/articles/s4158… 🧵⬇︎ CDN | King's College CNDD| King's College Institute of Psychiatry, Psychology & Neuroscience European Research Council (ERC) Rosetrees Trust

2/10 The cortex contains two main classes of neurons: excitatory “go” pyramidal cells and inhibitory “no-go” #interneurons

3/10 Neuronal activity operates within a tightly controlled range for the optimal functioning of #brain circuits. When synaptic connectivity and network activity are modified, such as when we are learning, compensatory mechanisms are needed to maintain stability

4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity

5/10 How is this achieved? We found that PV interneurons induce the expression of two genes encoding multiple neuropeptides, Scg2 and Vgf, in response to increased activity

7/10 For PV interneurons, Vgf is the critical gene modulating the plasticity of inhibitory inputs received from other PV interneurons

9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents European Research Council (ERC) and Rosetrees Trust

10/10 Here’s the paper nature if you want to dig in nature.com/articles/s4158… That’s it. Thanks for sharing! CDN | King's College CNDD| King's College Institute of Psychiatry, Psychology & Neuroscience European Research Council (ERC)

New paper from Julie Jézéquel and the Beatriz Rico on role of cadherins in neuronal inhibition out now in Nature Communications! rdcu.be/el18f