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Congratulations collaborative team lead equally by ⁦Gabby Tender⁩⁦@KayvonPedram⁩ and ⁦Judy Shon⁩, w/coworkers from ⁦Heinz Läubli⁩ and Weaver labs. Mucins drive cancer progression; we drugged them with targeted mucin proteases. nature.com/articles/s4158…

Congrats Anna Wuttig!

Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors biorxiv.org/cgi/content/sh… #bioRxiv

The Stark Lab MIT Dept of BE and Koch Institute at MIT opens January 2024! We are recruiting curious and motivated scientists at all levels. Learn more about our work and how to join our team: jstarklab.com 🧬 Please share widely! #immunoengineering #synbio #glycotime #newPI

Highly recommended! Working with @matthewmaddess and the DPC group was an amazing experience!

Replace an aromatic carbon with nitrogen, leave the rest of the skeleton the same. A huge first step towards the problem I started my lab to tackle, thanks to Tyler Pearson, Ryoma Shimazumi, Julia Driscoll 🇵🇸, Balu Dherange, and Dong-Il. science.org/doi/full/10.11…

Congratulations grad student ⁦Gabby Tender⁩ ⁦Sarafan ChEM-H⁩ on this review ⁦RSC Chemical Biology⁩. Lots of future opportunities for proximity-based medicines that target enzyme activities to cells and tissues. Especially for #glycotime targets. pubs.rsc.org/en/content/art…

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Out today in Science Magazine: Seeing glycans attached to proteins and lipids - at the *single molecule level*! 🎉🎉🎉 doi.org/10.1126/scienc… #ScienceResearch #glycotime #teammassspec My 1st #tweetorial🧵(1/n) 👇👇👇

We are hiring at multiple levels to join our team jstarklab.com MIT Dept of BE Koch Institute at MIT Apply below! Postdoc: tinyurl.com/3nufr3rp Lab Coordinator: tinyurl.com/3rhjvdf3 Tech: tinyurl.com/wud3hp6k Please repost! #immunoengineering #synbio #glycotime #newPI

✨#ImmuneDictionary✨is out today in nature! Paper nature.com/articles/s4158… Software immune-dictionary.org We created scRNA-seq dictionary of 17+ immune cell types responding to 86 cytokines in vivo, discovered the immune system is far more complex than previously known 1/

Thrilled to share my first preprint! TICTACs highlight the modularity of antibody-carbohydrate conjugates and their potential to act as highly tumor-specific immunotherapies. Shoutout to my collaborator Nick Till, and thank you Carolyn for your support!

So thrilled to have this long time coming paper publicly available! This was a really fun collaboration with Hanna M Ollila that we chipped away at together over many years. An innate immune checkpoint involved in platelet level maintenance - important to consider with anti-CD47.

Congrats to my labmate and good friend Lindsay Guzmán!

Glad to see our work on Genetically Encoded LYTACs (GELYTACs) in PNASNews. Highlights include directed evolution of GELYTACs & secretion of GELYTACs by primary T-cells. Special thanks to Alice Ting Carolyn Bertozzi, and collaborators @mackalllab. pnas.org/doi/10.1073/pn…

How thrilling to see this online after 8 years in the works!!! We showed that #Lyme bacteria mimic our own“don’t eat me” signal with their P66 protein to hide in plain sight!!! This tricks our SIRPa protein to trigger the breaks on immune clearance! biorxiv.org/content/10.110…

Online now: Probing enantioinduction in confined chiral spaces through asymmetric oxime reductions dlvr.it/TGyqfh