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3/ 🔬 Why NAPstars? Until now, getting a clear view of the NADP redox state across subcellular compartments was a major challenge. NAPstars offers real-time, specific, and pH-resistant measurements, providing insights that no existing tool can provide.

4/ 🌱🐁 From yeast to plants to mammalian cells, NAPstars have proven their versatility and robustness, revealing critical insights into how cells maintain redox homeostasis and respond to environmental cues like light and oxygen levels.

5/ 💡 One of several striking findings? The central role of glutathione as the primary mediator of anti-oxidative electron flux across different organisms. This challenges existing views and opens new avenues for research in redox biology.

6/ 🔄 We've observed NADP, NAD and H2O2 redox oscillations linked to the cell cycle in yeast and how plant leaves adjust their redox state in response to changes in light and oxygen. This level of detail was previously unimaginable.

7/ 🛠️ NAPstars will enable researchers across the globe and across disciplines to explore and understand the intricate web of redox processes that underpin metabolism and signaling in acclimation, disease and stress responses. Those are as old as RNA and underpin life itself.

8/ 🙏 A huge shoutout to our teams with Marie and Jan-Ole Niemeier as co-leads, our students and collaborators. Christopher Bell Johanna B Kroll @s_lichtenauer @jan_multhoff Messens Lab Jan Riemer

8/ 🚀 This is just the beginning, and we're excited to see where NAPstars will lead us all! 🔗 Again, here's the link to our preprint for a deep dive into our research: biorxiv.org/content/10.110…

Another great publication from the Deponte lab, looking at the mechanism of Grx1-roGFP2 sensors and glutaredoxins in general. Great fun to collaborate with Marcel on this, as always! nature.com/articles/s4146…

Looking forward to visiting Sao Paulo again! instagram.com/p/C4Iv5j0LKbe/…

Two professorships in Molecular Cell Biology and Systems Physiology in the Biology Department at Saarland University to be filled. jobs.zeit.de/jobs/professor… jobs.zeit.de/jobs/w3-profes… Please share!

Researchers have developed biosensors that can be used to measure the ratio of NADPH to NADP⁺ in living cells in real time for the first time. Universität Saarland Plant Energy Biology Lab Morgan_lab Jan-Ole Niemeier Jan Riemer Nature Communications doi.org/10.1038/s41467… & uni-muenster.de/news/view.php?…

1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins. biorxiv.org/content/10.110… This was another fantastic collaboration with; the Deponte Lab and Messens Lab.

2/ We also had the pleasure to work with Jan Riemer Johannes Herrmann, Ana Tomas' lab, Timo Mühlhaus' lab and Armindo Salvador on this exciting project.

3/ Long considered to only form homooligomeric complexes, we find that pairs of peroxiredoxins from human, yeast, plant and parasite readily assemble into heterodimers and heterodecamers.

4/ With Messens Lab and Julia Malo Pueyo, we used negative stain EM to visualise heterooligomers and show that heterooligomerisation strongly affects dimer-decamer equilbrium.

/5 We find that heterooligomerisation is inducible in response to oxidative challenge in yeast and stabilises Tsa1 as a Tsa1-Tsa2 heterodecameric complex

/6 With Jan Riemer, we could also show the presence of PRDX1-PRDX2 heterooligomers in HEK293T cells.

Armindo Salvador determined that it is possible to form as many as 120 distinct heterodecameric complexes with two monomeric components.

8/ The work now begins to understand the functional implications of peroxiredoxin heterooligomerisation and its implications for our current view of these fascinating proteins.

We are looking for a new colleague in the biology department at Saarland University! We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'. Please share! jobs.zeit.de/jobs/w2-profes…