Building and analyzing metacells in single-cell genomics data | Molecular Systems Biology embopress.org/doi/full/10.10…

Building and analyzing metacells in single-cell genomics data | Molecular Systems Biology embopress.org/doi/full/10.10…

Thrilled to see our paper "A Proximity Proteomics Pipeline with Improved Reproducibility and Throughput" published! It describes the automated enrichment of biotinylated proteins in a 96-well plate format for spatial proteomics and protein interactions. embopress.org/doi/full/10.10…

Evolution and stability of complex microbial communities driven by trade-offs | Molecular Systems Biology embopress.org/doi/full/10.10…

Integrating automated enrichment of biotinylated proteins with DIA-MS #proteomics for scalable proximity labeling applied to subcellular compartments in Ruth Huttenhain lab reveals proximal interaction networks induced by serotonin receptor activation ➡️ embopress.org/doi/full/10.10…

Review by M Basan lab discusses how #microbialcommunities flourish in long-term evolution experiments (#LTEE) rather than monocultures of a single fittest strain potentially as a result of trade-offs between competing microbial objectives ➡️ embopress.org/doi/full/10.10…

Excited that our study "Proteome-scale characterisation of motif-based #interactome rewiring by disease mutations" is published embopress.org/doi/full/10.10…. We show that disease-associated #mutations in the #IDRs both make a break #SLiM-based interactions. Short Linear Motif team Jakob Nilsson.

Our new paper with the Ylva Ivarsson & Jakob Nilsson teams characterising mutations in intrinsically disordered regions on a proteome-wide scale! We show numerous examples of disease-causing SNVs making and breaking SLiMs in work driven by Johanna Kliche. embopress.org/doi/full/10.10…

Many thanks to Kyle Allison at Emory for the insightful commentary on our recent MSB publication Multicellular dynamics and wealth distribution in bacteria | Molecular Systems Biology embopress.org/doi/full/10.10…

Our academic editor Yehu Moran is attending #Evol2024 in Montreal from 26-30 July. If you’re attending, please join him July 27th from 12:45-13:45 as he introduces our journals’ portfolio expansion in #ecology and #evolution. SSE Society of Systematic Biologists ESEB American Naturalist Evolution Meetings

Disease-associated genetic variations within intrinsically disordered regions can affect protein-protein interactions, as revealed by peptide-phage display #proteomics in the Ylva Ivarsson ➡️ embopress.org/doi/full/10.10…

N&V by K Allison on the study by Lingchong You lab discusses how rich multicellular communities of bacteria are stronger together in surviving antibiotic treatments through beneficial community interactions ➡️ embopress.org/doi/full/10.10…

Our paper "Identification of novel toxins associated with the extracellular contractile injection system using machine learning" is on the cover of Mol Syst Biol this month. A thread about a very peculiar and ubercool microbial toxin delivery system. embopress.org/doi/full/10.10…

A machine learning classifier is developed by Asaf Levy lab to identify microbial extracellular injection system #eCIS toxins ➡️embopress.org/doi/full/10.10…

Method by L Plate lab to map protein-protein interactions occuring over time by quantitative mass spectrometry reveals aberrant protein interactions in hypothyroidism #PPI ➡️embopress.org/doi/full/10.10…

Method to minimize error in crosslinking mass spectrometry analysis by Rappsilber laboratory ➡️embopress.org/doi/full/10.10…

Mosquitos prefer optimal codons whereas mosquito-born #dengue virus prefers non-optimal codons, which seems to be a common bias employed by hundreds of viruses shown by BazziniLab ➡️embopress.org/doi/full/10.10…

A subset of cancers identified by Joachim Weischenfeldt lab have hypermutation at CpGs associated with mismatch repair and TP53 driver mutations ➡️embopress.org/doi/full/10.10…

An updated genome-scale metabolic model of #yeast Saccharomyces cerevisiae is available as Yeast9, including mutant strain-specific #GEMs constrained by transcriptomics of ~1200 mutants ➡️embopress.org/doi/full/10.10…