Just a week left to register for the hybrid EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance", June 17-20, 2024, Leiden, NL. Speaker slots available! Register and submit your abstract before April 1, 2024! meetings.embo.org/event/24-chrom…

Thrilled to announce our latest research in Nature Cell Biology! We uncovered the crucial role of CSA and CSB proteins in repairing DNA-protein crosslinks (DPCs) in a novel transcription-coupled DPC-repair pathway. Erasmus MC MolecularGenetics@ErasmusMC Oncode Institute nature.com/articles/s4155…

Please join Karlene Cimprich her seminar by registering here: us06web.zoom.us/webinar/regist…

Happy to share our Nature Communications paper showing that prolonged TFIIH binding to nonexcised DNA damage causes severe neuronal and developmental failure. This can be prevented by depletion of XPA or TTDA, which stabilize TFIIH-DNA binding. nature.com/articles/s4146…

Happy to share the latest work of our lab showing the severe consequences of damage-stalled Pol II. Great work of Camila and Barbara! academic.oup.com/nar/advance-ar…

Happy to share our newest preprint on the function of the new TC-NER factor STK19. Great work of Anisha and Shun and a very nice collaboration with the Sixma lab @TitiaSixma. Erasmus MC MolecularGenetics@ErasmusMC Oncode Institute biorxiv.org/content/10.110…

Deadline just got extended…👇👇 Don’t miss this opportunity!

Nitika Taneja we are looking forward to your presentation at #BGFP25 in Portugal next July🌞! Registration is OPEN so please RT to let your followers know! For more info -🔗bit.ly/3AnsVZF

How are conflicts & R-loops rapidly resolved ahead of actively progressing forks? Is there a remodeler that associates with active forks, binds directly to R-loops, and senses & suppresses them? Check out our new study here!👇

De novo Heterochromatin (H3K9me1/2/3) assembly (by G9a) stabilizes stalled/stressed replication fork (by Hydroxyurea) Its timely disassembly by JMJD1A/KDM3A enables fork restart These heterochromatin dynamics are detectable at a time scale of minutes!😎 An intriguing explanation

Excited to share our guide put together by Calvin : Enhancing quantitative imaging to study DNA damage response... Together with Arnab Ray Chaudhuri , Proud of Calvin’s final contributions as first author, but certainly not the last! sciencedirect.com/science/articl…

Very excited to present the latest preprint from our lab! "FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments" biorxiv.org/content/10.110… .

What an exciting day for the lab at the Dutch Chromatin Meeting! Congrats to Ashutosh (a.k.a Vincent 😉)for winning the poster prize on 3D reorganization of stressed forks & Joanna for her fantastic talk on phase separation during replication stress. Proud of you guys! 🤩

Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025

Congratulations Sounak Sahu, Mélissa Galloux, members of our BRCA Variant Analysis Unit National Cancer Institute for this outstanding work. Sincere thanks to our collaborators Drs. Chari, Papaleo, Michailidou and their team members.

Please register here to join the seminar of Sven Rottenberg: us06web.zoom.us/webinar/regist…

Our latest preprint.. biorxiv.org/content/10.110…

Our lab’s insights on a recently published Science study that highlights ASB7 as a cell-cycle-regulated ubiquitin adaptor that restrains heterochromatin spread by targeting SUV39H1 for degradation. Check out our views & more of this exciting work 👉: nature.com/articles/s4139…