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Amyloidosis is everywhere - sometimes it matters, and sometimes not (as in this synovial sample; its absence in blood vessel walls is against clinically significant disease). Fayyaz AU, et al. Amyloidosis in surgically resected atrial appendages: a study of 345 consecutive cases

Fayyaz AU, Bois MC, Dasari S, Padmanabhan D, Vrana JA, Stulak JM, Edwards WD, Kurtin PJ, Asirvatham SJ, Grogan M, Maleszewski JJ. Amyloidosis in surgically resected atrial appendages: a study of 345 consecutive cases with clinical implications. Mod Pathol. 2020

Accumulating evidence shows that esophageal epidermoid metaplasia (the presence of a granular layer) is a precursor to squamous cell carcinoma. Here it is associated with high-grade squamous dysplasia, first studied in detail in Modern Pathology. Singhi AD, et al. Targeted

Singhi AD, Arnold CA, Lam-Himlin DM, Nikiforova MN, Voltaggio L, Canto MI, McGrath KM, Montgomery EA. Targeted next-generation sequencing supports epidermoid metaplasia of the esophagus as a precursor to esophageal squamous neoplasia. Mod Pathol. 2017 Nov;30(11):1613-1621. PMID:

No immunohistochemical stains are needed to diagnose this anal melanoma but Modern Pathology can help evaluate the anticipated outcome. Nagarajan P, Piao J, Ning J, Noordenbos LE, Curry JL, Torres-Cabala CA, Diwan AH, Ivan D, Aung PP, Ross MI, Royal RE, Wargo JA, Wang WL,

Myxoinflammatory fibroblastic sarcoma was first described in Modern Pathology using different terminology. It's one of the many legacies of Dr. Sharon Weiss, a grande dame of pathology. Montgomery EA, Devaney KO, Giordano TJ, Weiss SW. Inflammatory myxohyaline tumor of distal

There are so many wonderful vintage articles in Modern Pathology, including this classic on granular cell tumor. Note the pseudoepitheliomatous hyperplasia associated with this esophageal granular cell tumor. Filie AC, Lage JM, Azumi N. Immunoreactivity of S100 protein,

Filie AC, Lage JM, Azumi N. Immunoreactivity of S100 protein, alpha-1-antitrypsin, and CD68 in adult and congenital granular cell tumors. Mod Pathol. 1996 Sep;9(9):888-92. PMID: 8878020. #UMiamiPath Elizabeth Montgomery, MD Innovative Science Press

Despite new discoveries, we still need to remind our surgical colleagues that dermatofibrosarcoma protuberans tracks along connective tissue septa well past where the surgeon anticipates. Smith SC, Sweeney K, Evans MG, Angara K, Reynolds C, Price B, Park SJ, Elliott A, Oberley

This is truly an excellent opportunity for a #PathTwitter regular!

Here is a unique opportunity to be an editor for a USCAP journal.

SMAD4/DPC4 nuclear loss on immunohistochemistry can support an interpretation of pancreatic ductal adenocarcinoma even when there is signet ring cell morphology (this example is more typical). Simbolo M, et al. Clinical and Genomic Characterization of Pancreatic Ductal

Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan

Needle biopsy of a gastric glomus tumor; in this location, a neuroendocrine (carcinoid) tumor would be considered. These lesions sport various molecular alterations, but immunohistochemistry can confirm the diagnosis. Iwamura R, et al. PDGFRB and NOTCH3 Mutations are Detectable

Here is Editor-in-Chief Rhonda Yantiss discussing one of the best articles in Modern Pathology last year. Submit your articles and share your research! #PathX

This is a benign epithelioid peripheral nerve sheath tumor (schwannoma) of a digit. Modern Pathology offers some help in sorting out epithelioid skin lesions: Carter CS, Patel RM. Cutaneous soft tissue tumors: diagnostically disorienting epithelioid tumors that are not

Carter CS, Patel RM. Cutaneous soft tissue tumors: diagnostically disorienting epithelioid tumors that are not epithelial, and other perplexing mesenchymal lesions. Mod Pathol. 2020 Jan;33(Suppl 1):66-82.PMID: 31685962.

Once in a while gastrointestinal stromal tumors (GISTs) spread to bone! Learn about GISTs in less common primary sites: Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal

Hu S, Alpert L, Cates JMM, Gonzalez RS; Rare GIST Risk Stratification Group. Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs. Mod Pathol. 2022 Apr;35(4):554-563.

Synovial sarcoma can pop up anywhere - including the GI tract. This example is perfectly biphasic and has calcification at no extra charge. Ortiz Requena D, Longacre TA, Rosenberg AE, Velez Torres JM, Yanchenko N, Garcia-Buitrago MT, Voltaggio L, Montgomery EA. Synovial Sarcoma