A single-cell spatial transcriptomic and proteomic study of #immune cells in the human #CNS border compartments reveals differences in CNS-associated macrophages across age, perturbation and disease. Roman Sankowski #macrophages #microglia nature.com/articles/s4159…

A kicks neural circuitry into overdrive, coaxing tau entanglement from afar. Berkeley Neuroscience Uni Newcastle Research ow.ly/AqA050QlWw7

The stage was set for the next steps in #Alzheimer's research in 2018. See how researchers now incorporate new technologies & genetic diversity models to characterize the molecular pathways & subtypes associated with AD jax.org/alzheimers 🧠: resources.jax.org/therapeutic-ar…

Microglial AD risk gene INPP5D produces less functional protein in #alzheimersdisease brain, releasing the brakes on inflammation. Brigham and Women's Hospital ow.ly/S2Ji50QmjnB

The plasma Aβ42/40 ratio was three times lower in people taking the heart failure drug #Entresto than in people with brain amyloidosis. Entresto might confound #Alzheimersdisease blood test results. Göteborgs universitet / University of Gothenburg University of Glasgow ow.ly/ayIw50QmjBX

🧠 New brain network modeling tools were developed through MODEL-AD, a consortium of experts, which includes JAX. Read Pharmabiz.com to learn how they will use them in their pre-clinical investigations, including models of late-onset #Alzheimer’s disease: pharmabiz.com/NewsDetails.as…

Make sure to check this out! 👇 We are excited about it and hope you will be too #Alzheimers

'Proteo-genomics of soluble #TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for #AlzheimersDisease' Lihua Wang & Niko-Petteri Nykänen... Carlos Cruchaga NeuroGenomics and Informatics Center Test Account #microglia #APOE #Proteogenomics bit.ly/3vsSnug

Scientists found 15 risk factors for young-onset #dementia. Many also correlate with late-onset disease. Addressing the 14 that are modifiable might prevent both. Maastricht University ow.ly/5Mgo50QopES

'Comparison of immunoassay- with #massspectrometry-derived p-tau quantification for the detection of #AlzheimersDisease pathology' Joseph Therriault Marcel Seungsu Woo Gemma Salvadó... Rosa Neto, Pedro - McGill Research Centre for Studies in Aging McGill University Lund University #biomarkers bit.ly/47lSbdP

A new publication as part of our 'Glial and Vascular Contributions to Neurodegenerative Diseases' review series! Check out this exciting series, written by well-known experts in the field, on our website bit.ly/3OFQ8Kg

Paper alert from the UCI ModelAD center! Go check it out if you are interested in genetic diversity!!!

And another paper alert from the UCI ModelAD center! This time is about the interesting ABCA7 variant!

Check out the AlzPed webinar: An Open Science Tool Raising the Standards for Preclinical Testing of Candidate Therapeutics in Alzheimer’s Disease Animal Models   Date: April 30, 2024 Time: 12:00PM ET Registration link: us02web.zoom.us/webinar/regist…

📢 register now! Only a few seats left! jax.org/education-and-…

If you’re at #AAIC24, come by poster 16 today (Sunday) to learn more about the differential effects of the Apoe Christchurch variant on amyloid and tau pathology! MODEL-AD

Stop by to chat about data, animal models, and more! #AAIC24 MODEL-AD NIH

At #AAIC24, MODEL-AD consortium showcases growing menagerie of mouse models that reflect different flavors of Alzheimer’s disease. MODEL-AD ow.ly/PWCT50TrewU

Check out what we’ve been doing lately… alzforum.org/news/conferenc…

We are hiring!!! The UCI ModelAD team is seeking a highly motivated Database Research Specialist with expertise in data integration and metadata harmonization to support large scale animal model and genomics research efforts. Full position description: recruit.ap.uci.edu/JPF09537