Quality Control of the mitochondrial inner membrane through piecemeal mitophagy nature.com/articles/s4158…

It's out! Excited to share our latest work in Nat Comms. We found that mutant Huntingtin impairs human neurodevelopment in brain organoid models through early disregulation of the mitochondrial protein CHCHD2. Thanks to all coauthors! nature.com/articles/s4146…

A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria: Cell cell.com/cell/fulltext/…

It was a pleasure to organise this!

Interested in Ubiquitin, Parkinson’s disease therapy, mitochondria or DUB inhibitors? This preprint may be for you: We show how the deubiquitinase USP30 can specifically be inhibited & introduce a framework for DUB ligandability. biorxiv.org/content/10.110… Thread👇 – with movie!!

Interested in BNIP3/NIX-mediated mitophagy? Check out our new review, written with Jonathan Friedman, about recent advances in the field and our thoughts on the regulation of these mitophagy receptors in space and time. doi.org/10.1042/BST202…

Excited to share our latest study published in The EMBO Journal!!! 🙌🎉 We conducted a longitudinal analysis of physiological #mitophagy in healthy brain #aging, providing a deeper look at #autophagy pathways across neural space + time 🧠🔬 embopress.org/doi/full/10.10… #mitochondria

"Quantifying constraint in the human mitochondrial genome" nature.com/articles/s4158…

Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates | The EMBO Journal embopress.org/doi/full/10.10…..

Congratulations Swati Keshri! So interesting 🤓

"Cellular ATP demand creates metabolically distinct subpopulations of mitochondria" nature.com/articles/s4158…

New study from us: science.org/doi/10.1126/sc… High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.

cell.com/molecular-cell…

If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15 When mitochondria cannot flux energy properly, the cell

We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris Institut Pasteur, since 1887 All details on our web site : research.pasteur.fr/en/call/call-f…

So often with similar papers I find the imaging just isn’t good enough for me to actually see if the tagging has worked, sufficient expression/labelling density etc. Not the case at all here 😍😍. Noiiiiccceeee!

A novel function of the mitophagy receptor BNIP3! Adapting mitochondrial metabolism to the DNA damage response and mediating senescence 🧨

Red meat was a strong driver of omnivore microbiomes [..] negatively correlated with host cardiometabolic health. Conversely, vegan signature microbes were correlated with favourable cardiometabolic markers and were enriched in omnivores consuming more plant-based foods.

Dear community Due to the current developments, we have decided to discontinue our activities on X. We look forward to staying in touch with you on our other channels. #eXit #WissXit #ByeByeX #QuitX

MPI-DS Göttingen Let's all leave X. Next stop Blue Sky