Fascinating in vivo tracking of collective cell migration under confinement PNASNews! Reveals self-organized antiparallel streams and compressive ECM deformation. Now wondering: How do single cells navigate these complex microenvironments? 🤔 -LY www-pnas-org.libproxy1.nus.edu.sg/doi/10.1073/pn…

Thematic issue on Systems mechanobiology at npj Journals Systems Biology & Applications (guest editors: Fabian Spill, Tanmay Lele TAMU BMEN) now open for submissions. nature.com/collections/ic… Biomedical Engineering Society Mechanobiology Institute Mechanobiology News Physics of Life Dresden Mechanobiology & Microfluidics Research Group Abhijit Majumder Ian Wong Lab at Brown. 🟦ianywonglab

🚨 My 2nd AI novel is now published: The Reverse-Turing Club! Available on Amazon as a Kindle e-book or in paperback. Check it out! 🤖📖 a.co/d/dqIZX3l

Super excited to share the latest paper from my group published in Science Advances . "Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts" Johns Hopkins BME Johns Hopkins ChemBE The Johns Hopkins Institute for NanoBioTechnology Johns Hopkins Engineering Johns Hopkins University science.org/doi/10.1126/sc…

Excited to share our new publication nature.com/articles/s4146… , showing that viscoelastic matrix enhances cell plasticity and reprogramming efficiency. Congratulations and thanks to Yifan Wu, the team members, and collaborators!

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and how does this relate to #mechanobiology? Learn more in our recent review by Sarah Henretta now out in npj Journals - biological physics and mechanics (doi.org/10.1038/s44341…).

Immense congrats to my amazing postdoc Debanik Choudhury, PhD for winning the Best Poster Award at the 18th Nano-Bio Symposium at The Johns Hopkins Institute for NanoBioTechnology ! In just one year, he’s co-led a COCB article doi.org/10.1016/j.ceb.……, a book chapter , and has several more in the pipeline. Well-deserved!

Fresh science! Check out our Confinement Mechanobiology Lab at MBI’s new paper on how confined migration can drive stem cell differentiation in Advanced Portfolio News. Let’s do a thread! advanced.onlinelibrary.wiley.com/doi/full/10.10… (1/n)

A must read paper from the Holle lab!

If your stack of images is full of defects, don't panic! InterpolaAI, a deep learning-based optical flow method, will fix issue tears, photobleaching and sticking artifacts for improved 3D imaging. Read our paper in Nature Methods: nature.com/articles/s4159…

It’s been a long time coming but… so happy my Ph.D. work (part of) is now published on Nature Materials 🥳 I remember it all too well about this project, the serendipity and the exciting stories…🧵Jennifer Young Mechanobiology Institute NUSBME NUS nature.com/articles/s4156…

🚨 New publication!🚨 We explored how chaotropic salts shape protein coronas on polymersomes. Divalent salts, esp. calcium, had the biggest impact—forming hard coronas rich in calcium-binding proteins. Exciting implications for #polymer #nanomedicine doi.org/10.1016/j.jcis…

There’s tons out there about fibroblast #mechanobiology in disease. In Confinement Mechanobiology Lab at MBI’s new review in APL Bioengineering, Yeji gives you the who/what/where/when/how/why of mechanosensitive fibroblast activation, from CAFs to FAFs and nearly everything in between! pubs.aip.org/aip/apb/articl…

I'm pleased to announce that CMBE now has an impact factor of 5.0! And don't forget, there is no publishing fee.

Thrilled that our newest work led by Avery, Dr. Wisniewski, and Panagiotis Mistriotis is out today in Nature Materials! We show how the cytokinesis proteins Anillin and Ect2 drive RhoA/ROCK/myosin-mediated invasion in confining spaces in vitro and in vivo. doi.org/10.1038/s41563….

Check out our lab's latest review by 𝑭𝑨𝑹𝑰𝑺 Mechanobiology Institute NUSBME in Current Opinion in Cell Biology Elsevier | ScienceDirect 🔗sciencedirect.com/science/articl… We teamed up w/Brian Aguado UC San Diego Bioengineering to highlight region- & sex-specificity of #ECM signaling in the aging heart!🫀 Hope you enjoy!

Please spread the word about this foundation dedicated to dilated cardiomyopathy caused by mutations in the LMNA gene. It helps connect patients and provide them with resources and connections to clinicians and researchers.

In our new paper, we produced a 3D single-cell reference map to guide the design and validation of a new multi-compartment assembloid that mimics the function and architecture of the human endometrial tissue, exhibiting stromal decidualization. More here: biorxiv.org/content/10.110…