Michael Hoetker
@michaelhoetker
Physician-scientist studying cell fate corruption in cancer | Heidelberg University Hospital @uniklinik_hd
ID: 1288213051770933248
28-07-2020 20:41:50
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37 Followers
48 Following
New #JITC article Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models bit.ly/3Kd8LCi Alec Griffith
Happy to contribute a News & Views piece on an interesting new paper Nature Cell Biology! The study provides intriguing evidence that loss of cell identity and gain of plasticity during reprogramming and malignant transformation are uncoupled processes. nature.com/articles/s4155…
🧋NEW: Michael Hoetker et al. show that #H3K36 #methylation exerts a dual role in #cellidentity maintenance: it integrates TGFβ signals at #mesenchymal targets to keep them active and prevents alternative lineage program activation. rdcu.be/dhBbZ nature.com/articles/s4155…
🎁Interested in learning more about the study? Read also the N&Vs article written by Eran Meshorer and Lea Rachel Zehava Cohen: rdcu.be/dhBcs nature.com/articles/s4155…
1/Excited to share our latest study showing that RNA sequestration in P-bodies sustains myeloid leukemia - now out in Nature Cell Biology! nature.com/articles/s4155…. 🧵 below:
We’re happy to share our new study out today Nature Cell Biology We show that a chromatin factor, ZNF280A, is required for DNA double strand break repair, linking its absence to clinical features in 22q11.2 distal deletion syndrome. Mostoslavsky Lab nature.com/articles/s4155…
1/ Excited to share our new study with Brumbaugh Lab, now out in Nature Biotechnology! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵nature.com/articles/s4158…
