U-ExM microscopy on mouse #retina reveals a novel structure inside the #photoreceptor connecting #cilium, the #InnerScaffold, that protects the outer segment against degeneration (a leading cause of #blindness) Mercey Olivier @CentrioleLab #PLOSBiology plos.io/3b7HQKN

Potential for #RetinitisPigmentosa treatment: Team from @UNIGE_en & Université de Lausanne identified role of absent “molecular zipper” in retinal cells. Restoration by injecting missing proteins could help prevent cell death. Mercey Olivier @CentrioleLab PLOS Biology: bit.ly/3nc7UHL

Building Sight – Scaffold' supporting retinal #photoreceptors – lost in #retinitispigmentosa – revealed by expansion #microscopy. Image & research by Mercey Olivier et al @CentrioleLab Biologie - UNIGE in PLOS Biology. More on bpod.mrc.ac.uk/archive/2022/8… with MRC Laboratory of Medical Sciences (LMS) & Dr Soph Milbourne

Post-doctoral positions in Molecular Biology, Cell Biology or Genetics now open in our team at IOB.ch, in beautiful Basel, #Switzerland. For more information and to apply: jobs.dualoo.com/portal/xxjgcad… #molecularbiology #genetics #postdoc #postdocposition #postdoctoral

Thrilled to present my PhD work about the development of #iUExM 🥳 Here, we introduce an optimized versatile protocol using iterative expansion to reach #SMLM resolution on conventional widefield or confocal fluorescence microscopes on cells & tissues. biorxiv.org/content/10.110…

📢Job opportunity - oceanic symbioses We have European Research Council (ERC) funded PhD and Postdoc positions in the lab to work on the SymbiOcean project. Interested to apply 3D cryoimaging to learn more about cell-cell interactions in the ocean? please contact me or RT 🦠

Elsevier's revenue: £2.9 billion. WTF? We scientists produce the content for manuscripts and review for free. Then we pay huge fees for open access publishing. Science should not be business. What on earth can we do to fight against this? theguardian.com/science/2023/m…

So happy and honored to have received the Swiss ophtaward from the SOG-SSO. I'm truely convinced that expansion microscopy represents a promising tool to study mechanisms of retinal diseases

So Amazing to see the subcellular readout of gene therapy and FAM161A that relocalizes exactly at the same position as physiologically, allowing to restore photoreceptor function

Some 25 fold expanded Chlamydomonas cells with #iUExM coupled to #TREx (iU-ExM-T) with 20X air objective on widefield microscope🤩 Microtubule doublets are visible🙃 (Scale bars are not corrected with expansion factor)

300/344... Soon!😊

Its out !!! 🥳 Very proud to announce that my PhD work is now published in Nature communication: nature.com/articles/s4146… We developed #iUExM, an optimized iterative expansion protocol allowing 16 to 26 fold homogeneous expansion together with specific bright labelling !

I'm Thrilled to have received the Retinaward 2023 for the best experimental project, soon after having received the Ophtaward. Thanks to the Swiss VitreoRetinal Group from the SSO to have chosen my project, and Bayer-Roche-Novartis for sponsoring.svrg.info/news/

📣 Hot off the press: Transitional arrangements will allow the ERC to begin accepting applications from researchers based in 🇨🇭Switzerland once again, as from the calls under the ERC’s 2024 Work Programme. Statement from the ERC's Scientific Council 👇 erc.europa.eu/news-events/ne…

Just under 9 months to go to Cilia2024 on Sept 10-13, so save the date. Fantastic program and speakers lined up - check us out at cilia2024.ie. Registration opening in February.

So happy to share this new collaborative work. We notably used expansion Microscopy to assess subcellular reexpression of FAM161A after gene therapy, correlating functional rescue to optimal subcellular relocalisation.

Here is our last review with Souradip Mukherjee From @CentrioleLab offering new (architectural) vision of the ciliary transition zone: sciencedirect.com/science/articl…

I am deeply honored to receive the 2024 Basic Research Award from ProRetinaDE and Retina Suisse. I sincerely thank both foundations for their generous support of young researchers.