Best lab team ever! They got me good with a surprise birthday cake during a 'meeting.' Feeling so grateful and lucky to work with such amazing people!

Out in Cell now with added data and analysis! Huixin and colleagues report that the choroid plexus has specialized epithelial-immune synergy that modulates epithelial barrier plasticity during brain inflammation. authors.elsevier.com/sd/article/S00…

We're excited to share our new study on the role of the ABCA7 gene in brain resilience against #Alzheimer’s. Published in Cell Genomics, we found that ABCA7 is crucial for maintaining synaptic health by regulating #neuropeptide Y (NPY), a key molecule for brain communication and

CD8 T cells exacerbate AD-like symptoms in mouse model of amyloidosis sciencedirect.com/science/articl…

Excited to share a new work from Kipnis Lab by amazing Wenqing Gao (twitter-less) on developing engineered T cell therapy for CNS injury || nature.com/articles/s4158…

Lipid-laden macrophages cause immunosuppression and their transfer of lipids to brain tumours fuels cancer growth go.nature.com/4goO6v9

Excited to see our paper on the MAP chip, a microfluidic device profiling human monocyte migration under various chemotactic and barotactic cues, while assessing age and cytokine effects, highlighted on the cover of Cell Reports Methods cell.com/cell-reports-m…

Emerging roles of astrocytes as immune effectors in the central nervous system dlvr.it/TDm6xb #immunology

Honored to be acknowledged by nature for our many contributions to Alzheimer's research: 1987-discovery of first Alzheimer's gene, APP, 1995-discovery of 2 more Alzheimer's genes, PSEN1&2, 2008-discovery of the first microglial Alzheimer's gene, CD33. nature.com/immersive/alzh….

The history of Alzheimer’s disease (1906-2024) nature.com/immersive/alzh…

Congratulations again to Rudolph Emile Tanzi (Dr. Rudy Tanzi) of Mass General Brigham for being elected to the National Academy of Medicine last year! #NAMclassof2023

Happy Halloween from the Jorfi lab!! MGH Neurology

Approaches for studying neuroimmune interactions in Alzheimer’s disease dlvr.it/TG8M2S #immunology

Very excited to share our new paper in Trends in Immunology! We discuss how peripheral immune cells, especially T cells, shape AD pathology and outline state-of-the-art models to study neuroimmune interactions. Shoutout to Jerry Lin, Yuyao Tian & Dr. Rudy Tanzi authors.elsevier.com/a/1k5As5Eb0Rxn…

Just out in Neuron! Check our manuscript on Alzheimer’s Disease (AD) therapeutic target discovery led by Sang Su Kwak and myself in a joint effort between Kim, Dr. Rudy Tanzi , and @winhide Laboratories. Paper link: authors.elsevier.com/c/1kATc3BtfH9B… #Neuroscience #Alzheimers 1/n

I'm thrilled to see our paper featured on the cover of Trends in Immunology! We discuss how peripheral immune cells contribute to Alzheimer’s disease and highlight new approaches to studying neuroimmune interactions. paper: dlvr.it/TG8M2S MGH Neurology Harvard Medical School @MGH_RI

Neuroinflammation in Alzheimer disease | Nature Reviews Immunology nature.com/articles/s4157…

Immune mechanisms and shared immune targets in neurodegenerative diseases nature.com/articles/s4158…

Today marks the 1st anniversary of the Jorfi lab! This past year has been full of challenges, growth, and exciting discoveries. I’m so proud of everything our team has accomplished and grateful to work with such an amazing group. Looking forward to more milestones ahead!

Thrilled to share our new paper in @Neuron exploring how a gain of function missense mutation, T96K, in the TREM2 gene increases risk for Alzheimer's disease by lowering levels of soluble TREM2 leading to dysfunctional microglia — now online: