1) Study finds healthy lab-grown muscle exposed to ME/CFS or Long COVID blood quickly loses strength, temporarily boosts metabolism, then undergoes mitochondrial and structural collapse with prolonged exposure. Distinct metabolic and structural differences separate ME from LC.

A very moving, sad and beautiful video about severe ME from my friend Anil van der Zee ©. He posted it to mark the awareness day for severe ME, which was on Aug 8th. youtube.com/watch?v=qVDwvt…

Study Shows that Mitochondrial Dysfunction in Long COVID and ME/CFS is a CONSEQUENCE or EFFECT. and the ROOT CAUSE is at the Vascular Level, which can be transmitted through the blood: iopscience.iop.org/article/10.108… Findings support our statements from years ago: x.com/Aguirre1Gustav…

Got a question about our results? Our FAQs page has more information about our initial genetic results and what they mean for people with ME/CFS: shorturl.at/y4CwG . You can also join our webinar on Thursday where there will be a Q&A session: shorturl.at/fmrwl

The latest paper from the Cornell ME/CFS Center is in PNAS today. RNA released into the blood differs in cases vs sedentary controls, who can be distinguished at 77% accuracy. Biological network analysis shows dysfunction of the immune system in ME/CFS, as in other assays.

1) A thread for people worrying that the DecodeME effect sizes are too small… In an interview with David Tuller, Prof. Chris Ponting pointed out that "just because the human genetics gives a small effect size, does not predict the effect size of an intervention like a drug."

US press release: Researchers identify key biomarkers for chronic fatigue syndrome news.cornell.edu/stories/2025/0… #MEcfs #CFS

....and from 1978... rfh1955.blogspot.com/2024/01/long-c…

#Thankyou #DecodeME

Community Symposium on the Molecular Basis of ME/CFS returns Sept 5 on zoom! 8am-1pm PST Attendance limited to 5,000. Registration required and can’t be shared. Registration link: stanford.zoom.us/webinar/regist… See photo below:

The “psychologisation” of ME/#CFS has been part of the problem as we’ve said before and, sadly, will keep having to say. As a psychologist, it’s especially important to be clear and amplify: every year, science confirms more — this is a biological illness. tinyurl.com/mtaap45f

Neurologist here and I am so done with this. “Teaching your brain and body new ways of doing things” is not why you recovered. You were lucky to get back on track. Media, stop misleading people and show kids like ours Erin M Swiftsandswallows Solitary Native Bee, PhD who are bedbound

These words are from Ziyad Al-Aly’s speech at #KeystoneSymposia. I wish I could edit nancy klimas ‘s video so it plays right after Al-Aly’s speech, when she says “o-oo here we go again,” but the symposium cannot be shared. So please read Al-Aly’s words first, then watch Nancy

There is no threshold for exertion under which a patient with PEM experiences normal exercise physiology. It is a lie rooted in ableism and toxic workout culture. The science is clear - any amount of exertion causes muscle, mitochondrial, and neurological dysfunction.

This meta-analysis from a Lancet journal promotes exercise for Long COVID, although most of the trials included are at high risk of bias and quality of evidence for 84% of the outcomes were of either low or very low quality. virology.ws/2025/08/16/tri…

I’m excited to share the first part of an absolutely stunning analysis from the GPT-5 thinking model! I uploaded a huge spreadsheet, nearly 1,300 metabolites (lipids, carbohydrates, microbiome-derived compounds, and much more) measured in 150 ME/CFS patients and 100 healthy

“If somebody wanders into an emergency department with their arm lopped off, you don’t walk up to them and say, gee, you seem upset about this arm being lopped off, should we set up an appointment with a psychologist so you can talk about it? No, you address the missing arm,

Be sure to register! Agenda coming out soon

#MEcfs few psychiatrists hijacked illness, claimed treated by CBT & GET, enlisted CMO at DWP, got £5mn for 'definitive trial', found no evidence, changed analysis, claimed success, used Lancet & SMC smear patient critics, spent £100sK hide data, proper analysis found no evidence