There’s a new #COVID19 #SARSCoV2 wave. Partial immunity due to prior infection/vaccination prevents more severe disease in majority of healthy persons, but higher risk for vulnerable remains. Everyone’s at risk for #Longcovid. Masks at least in crowded space reduce infection risk

And if you’re sick, stay at home. If you are an employer, encourage your staff to stay at home when they are sick. Sick workers coming to work will lead to more sick workers and ultimately more absence, and exhausted staff.

Who wears masks nowadays? Informed people. Compassionate people. Responsible people. Community-minded people. Wise people. Strong people. Scientifically literate people. Realistic people. #YallMasking

Can AlphaFold be useful in drug discovery? Hell yes! In our paper, structure-based virtual screens using AlphaFold models identify potent GPCR ligands with antipsychotic effects in vivo (science.org/doi/10.1126/sc…). KAW @UU_University Karolinska Institutet SciLifeLab

Is the esterification of a carboxylic acid a common strategy to increase the brain permeability of a candidate drug (peptide or small molecule)? Thx🙂

❗️Remission Tweet for ME/CFS and Long Covid ❗️ Let’s create a collection tweet of all remission events. It doesn’t matter if it was for a couple of hours, days or weeks. Was it like a switch ? Or like a longer process ? Tell us a bit about the circumstances. What happens the

A quick reminder of our next #Zoominar session on Thursday, November 7th at ***10:00 am CET and 8:00 pm AEST***. Do not miss it, especially if you are interested in structural biology and protein structure visualization.

wow🤩

Paper just out in Science. We are one mutation away from Human-to-Human transmission of #H5N1 #BirdFlu We are so screwed... science.org/doi/10.1126/sc…

Interested in doing a #PhD in the field of #cellbiology and #pharmcology? We have an open PhD student position and develop novel optical to investigate how heterotrimeric #Gproteins enable #GPCR-specific signaling. Please repost :) stellenangebote.uni-marburg.de/jobposting/646…

📍Off-label Liste für ME/CFS & PAIS verfügbar📍 Nach der Ankündigung auf unserem Symposium und viel Arbeit gibt es nun eine off-label Liste für #MECFS und PAIS. Sie ist auf der Seite des Referenzzentrums verfügbar. Die gelisteten Medikamente sollen ab sofort von den

🗞️The highlight authored by Prashant Rajbhandari et al. comments on the recent breakthrough in appetite regulation. 🌟The secretory peptide neurotensin in white adipose tissues regulates food intake. 🔗 nature.com/articles/s4142… nature.com/articles/s4142… Thanks to the scientists

Congratulations Susruta Majumdar and team! A cryptic pocket in CB1 drives peripheral and functional selectivity | Nature

Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator 連結したペプチドをNTSR1のC末に連結させBAM付きアレスチン構造を高分解能で と言う、お話。アレスチン複合体にしては分解能も密度も良いな nature.com/articles/s4142…

Happy to share our work on the allosteric regulation of FFA2 receptors! It was a great collab. with the Ishikita, Dror Lab, and 東北大薬・分子細胞生化学(井上研) labs. Congrats to Mai, Kouki Kawakami, Ryoji, and everyone involved! nature.com/articles/s4146… (1/n)

I help 2 new founders pro bono. They are developing an AI tool to suggests stable GPCR constructs for expression & structural studies. To get a better grip on pricing I would use the help of #biotech community so pls RT. What are typical license fees & costs for a GPCR structure

ME/CFS is not rare. It’s ignored. Every May, we raise our voices for the millions who can’t. From 2020 to 2025, nothing has changed fast enough. We’re still here. Still missing. Still fighting. #MillionsMissing #MECFS #InvisibleIllness #MEAwarenessMonth Repost it for awareness !!

Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain: Cell cell.com/cell/fulltext/…

Nice thread!🔥