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🚨📄PREPRINT ALERT! "New antiviral defences are genetically embedded within prokaryotic immune systems" ⚔️🦠 #phage biorxiv.org/content/10.110…

go R2!! 🐦‍⬛🐦‍⬛ this is a very lovely study 😍

Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in Genomics England ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9

The fly has a full #connectome, basically a directed + weighted graph. But what are its connection ‘signs’, excitatory/inhibitory? We move towards this answer, predicting transmitters from EM! w/Nils Eckstein, vid Amy Robinson Sterling, 1/n Published Cell: cell.com/cell/fulltext/…

In our newest preprint, • we explore the effects of synonymous genome recoding, and • construct & troubleshoot a synthetic 57-codon E. coli genome using multi-omics, editing, and laboratory evolution. 1/n

Nils's incredible work is finally out, amazing work on a multi-talented protein by a multi-talented postdoc! It was a joy to use Dari Dari Kimanius 's new Blush algorithm in #RELION to solve the cryoEM structure of this 40 kDa RNA complex

considering making a high-effort molecular movie for an upcoming paper (!) but am slightly worried Twitter / Xitter will implode before I get to post it 🥲

Such a crazy discovery. I think this captures the reaction of the audience while watching Max Wilkinson present this at the Symposium on the Immune System of Bacteria.