#JournalClub "We’re born as genomic mosaics, each cell unique. With age, this diversity is overtaken by a few dominant clones — a shift linked to frailty. Mack et al. dive into large human datasets to uncover what drives this process." - Mate Maus nature.com/articles/s4358…

🚀 Recently, we welcomed Sefora Conti as our #JournalClub invited speaker! She shared how she has used tools from mechanobiology, meta-analysis, and bioinformatics to uncover what drives metastasis in gastrointestinal tumors. 👉vhio.net/pf/upper-gastr…

50 people committed to changing science, policy, and medicine in Spain - preparing for the coming tide of rising cancer incidence in the decade ahead. It has been humbling and inspiring to be part of this effort. FERO Retreat, Valencia - Fundación Fero

"Yu-Jung Tseng and colleagues Daisuke Nakada show that iron acts as a critical signal to activate splenic blood stem cells for red blood cell production during acute anemia — in a TET2-dependent manner." - Ning Huang, PhD student #JournalClub nature.com/articles/s4146…

Imagine a world where you can choose your child’s traits or rewrite your own genes to cure disease or extend life. This month, we recommend The Gene by Siddhartha Mukherjee — a gripping history of how we came to understand, and are beginning to rewrite, the code of inheritance.

Francesca Cogo (PhD student) at #JournalClub: Danian Chen et al. show that shorter cell cycle duration increases susceptibility to tumor initiation—making it a key hallmark of cancer initiation. nature.com/articles/s4158…

Mate Maus at #JournalClub: Fascinating study from Miriam Merad, MD, PhD’s lab suggests our aging immune system may drive cancer. With age, bone marrow–derived monocyte-lineage cells replace resident lung myeloid cells — fueling tumor growth via IL-1 secretion. 👉science.org/doi/10.1126/sc…

Tatiana Cañeque et al. (Rodriguez lab) develop Fento-1, a new molecule that eliminates therapy-resistant CD44⁺ cancer stem cells by targeting lysosomal iron and inducing ferroptosis. Presented by PhD student Francesca Cogo at #JournalClub. nature.com/articles/s4158…

Atherosclerotic burden drives cardiovascular events in the elderly. José Javier Fuster et al. showed TET2-mutant blood cells—common in elderly—accelerate atherosclerosis. Aging bone marrow may fuel cardiovascular aging. Ning Huang #JournalClub. science.org/doi/10.1126/sc…

🚀 Recently, we welcomed Agnese Brischetto as our #JournalClub invited speaker! She shared insights into the biology of psoriasis—an autoimmune skin condition affecting ~3% of the population—along with intriguing findings on potential new treatments. 👉clinicbarcelona.org/en/idibaps/are…

Krotenberg et al. @SasSuijk lab created fluorescent mixed organoids to study cell competition in colorectal cancer. They show cancer cells actively eliminate wild-type neighbors via JNK signaling to fuel their growth. Marc Guasch #JournalClub 🔗 cell.com/iscience/fullt…

For colon cells to form cancer, they must acquire mutations—but how do early mutant clones expand? Louis Vermeulen et al. use lineage tracing to show that competition with wild-type cells is real, and chance dominates. Marc Guasch #JournalClub science.org/doi/10.1126/sc…

Cellular hypermetabolism drives aging and age-related disease. Gkioni et al. (Partridge lab) show that targeting two independent growth/metabolism regulators synergistically extends lifespan and delays cancer in aging mice. Mate Maus #JournalClub nature.com/articles/s4358…

An increasing number of young individuals are being diagnosed with colorectal cancer. This week, we hosted medical oncologist Iosune Baraibar, who shared what she at Vall d’Hebron Institute of Oncology (VHIO), and Dana-Farber collaborators are doing to understand and act on this epidemic. Honored to work at Vall d’Hebron Institute of Oncology (VHIO).

Hereditary hemochromatosis related iron overload accelerates age-related cardiac hypertrophy in a mouse model. Francesca Cogo #JournalClub nature.com/articles/s4159…

We are all born with blood cells that could turn into cancer. But aging and chemo don’t just damage cells—they differently pick the bad ones. Chemo favors TP53-mutant clones giving rise to therapy-related MDS. #JournalClub Ning Huang nature.com/articles/s4140…

Intestinal stem cells (ISCs) with APC mutations outcompete wild-type ISCs by suppressing Wnt signaling in their neighbors - driving colorectal tumor formation. Exciting work from Louis Vermeulen’s lab! Presented by Marc Guasch @JournalClub nature.com/articles/s4158…

What makes a bag of cells become a complex, intelligent being—and what breaks those rules to cause aging and system breakdown? Donella Meadows’ Thinking in Systems offers a toolkit to understand biology, society, and the economy in their native language: systems. #LabReads 📚

In a preprint, Han et al. from Yibin Kang’s lab report that cancer cells in bone metastases hijack iron from bone marrow macrophages that normally support red blood cell production — linking anemia to metastatic progression. #JournalClub biorxiv.org/content/10.110…

Longer lives in laboratory conditions may compromise survival in real world. In a large study on genetically diverse mice, Andrea Di Francesco et al. The Jackson Laboratory show that lifespan extension under caloric restriction doesn’t always improve health. #JournalClub nature.com/articles/s4158…