UniQure's AMT-130 just became the first treatment to significantly slow progression of Huntington's disease (based on a phase I/II trial). High-dose patients declined ~75 % less over 3 years vs matched controls. ([University College London][1]) Some even returned to work after

Big announcement day for us. DVC now manages a family of funds and with the addition of our fresh $75M Series A AI fund we’ll be able to continue backing the amazing founders we’re privileged to work with and build more support structures for them. Thanks to my partner in crime

Microsoft is playing catch-up in consumer AI by licensing Harvard Health content for Copilot. Copilot "only" has 95M downloads vs ChatGPT's 1B+. But this makes sense for Microsoft and healthcare makes sense as a lane for them. My issue: licensing content ≠ clinical validation.

Our advisor Spencer Dorn just published a smart piece in Forbes on how AI is reshaping healthcare's front door, from general chatbots to purpose-built clinical systems. Spencer traces the democratization of medical knowledge from 19th-century home guides to today's AI tools. I

Really looking forward to shaping the future of healthcare at #HLTH2025 in Las Vegas. Odds are AI innovation wins big.

I love this. A child was born profoundly deaf: she couldn't hear drums and cymbals banged behind her head at the highest testable levels. At 11 months old, she received a 15-minute gene therapy procedure that delivered a working copy of the OTOF gene into her right cochlea. Two

Medicare Advantage just hit a milestone nobody wanted: the first enrollment decline in nearly two decades. Nearly a million fewer people are expected to sign up in 2026, dropping from 34.9 million to 34 million enrollees (this is also apparently a conservative projection...).

This is really interesting. Galleri's Pathfinder 2 results presented at ESMO show their multi-cancer blood test detected over 50 cancer types with 60%+ positive predictive value and ~99% specificity. When added to standard screening for breast, cervical, colorectal, and lung

Pretty interesting given how inexpensive topical steroids are: Cancer Research UK Manchester Institute found topical steroids shrink melanoma tumors by reducing levels of Garp protein on tumor cells, which reactivates immune response against cancer. Analysis of data from over

Health insurers are cutting back on unprofitable Medicare Advantage plans, raising out-of-pocket costs, and shrinking provider networks. At the same time, physician appointment wait times have increased 19% in just three years. The system is telling us something: access is

Healthcare AI market map by Menlo Ventures

The federal government shutdown that began October 1 eliminated funding for community health centers, the National Health Service Corps, and Medicare telehealth flexibilities. Medicare telehealth now reverts to pre-pandemic restrictions: limited to rural areas, patients cannot

Johns Hopkins scientists have developed a way to build immune "hubs" inside tumors that normally hide from checkpoint inhibitors. By activating two immune-signaling pathways (STING and LTβR), they triggered formation of tertiary lymphoid structures--mini immune organs that

I said this before, but it needs to be repeated. With Congress failing to renew pandemic-era telehealth rules, Medicare flexibilities expired October 1. Patients can no longer receive most primary-care video visits from home, and audio-only coverage ended for many services. Rural

Ok, hear me out on this one... Maybe we're not too far (5 years?) from AI prescribing SOME medications? Maybe some medications need a doctor's judgment, but not a doctor's signature? Take UTIs. Clear symptoms, established protocols, known resistance patterns. Yet people wait

A Korean randomized trial found that very low-dose radiation therapy eased osteoarthritis knee pain without side effects. Among 114 participants, 70% receiving 3 Gy of radiation reported meaningful pain and function improvement, compared with 42% given sham treatment. The

UC Irvine scientists reversed age-related vision loss in mice by restoring omega-3-derived fatty acids produced by the ELOVL2 enzyme. Supplementing these lipids improved photoreceptor health and retinal function. The team also identified ELOVL2 gene variants linked to faster

Johns Hopkins researchers discovered that neurons form ultra-thin "dendritic nanotubes" that ferry amyloid-beta between cells--potentially spreading Alzheimer's pathology. In mouse models, these nanotubes appeared early in disease, before major plaque buildup, suggesting a new

Medicare Advantage insurers are pricing for profitability rather than growth, leading to the first enrollment decline in 15 years. Translation: traditional healthcare economics can't sustain accessible primary care at scale. Consider the math. The U.S. will face a shortage of

A US hospital billed $195k for a four-hour ER visit (where sadly, the patient died). The pricing is totally predatory so the brother in law uses Claude to expose this. He negotiates the bill down to $33k by catching all the Medicare billing violations. Healthcare is broken in