Matt McPartlon (@mattmcpartlon1) 's Twitter Profile
Matt McPartlon

@mattmcpartlon1

Co-Founder at Chai Discovery

ID: 940762106529570816

calendar_today13-12-2017 01:55:39

21 Tweet

80 Followers

75 Following

Stanford AI+Biomedicine Seminar (@stanford_ai_bio) 's Twitter Profile Photo

Next Tuesday, we are super excited to have Matt McPartlon from Chai Discovery to share Chai-1, a foundation model for molecular structure prediction that performs at the state-of-the-art! Join us!

Next Tuesday, we are super excited to have <a href="/Mattmcpartlon1/">Matt McPartlon</a> from <a href="/chaidiscovery/">Chai Discovery</a> to share Chai-1, a foundation model for molecular structure prediction that performs at the state-of-the-art! Join us!
Martin Pacesa (@martinpacesa) 's Twitter Profile Photo

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

Sergey Ovchinnikov (@sokrypton) 's Twitter Profile Photo

Exciting new work from Qian Cong's group on predicting human protein interactome. Leveraging new eukaryotic genomes, new RoseTTAFold2 trained on +/- pairs of PPI and large distilled dataset of domain-domain interactions! 🤩 biorxiv.org/content/10.110…

Exciting new work from Qian Cong's group on predicting human protein interactome. Leveraging new eukaryotic genomes, new RoseTTAFold2 trained on +/- pairs of PPI and large distilled dataset of domain-domain interactions!  🤩

biorxiv.org/content/10.110…
Chai Discovery (@chaidiscovery) 's Twitter Profile Photo

Today we’re releasing Chai-1r, an updated version of Chai-1 with full support for restraints. Prompting Chai-1r with prior structural knowledge can boost accuracy by >2x. github.com/chaidiscovery/…

Chai Discovery (@chaidiscovery) 's Twitter Profile Photo

Chai-1 has always been available for commercial use via our server. Today, we're also making Chai-1(r) code and weights available under an Apache 2.0 license, which permits broad commercial use. github.com/chaidiscovery/…

Chai Discovery (@chaidiscovery) 's Twitter Profile Photo

We're excited to partner with the UK Government on OpenBind, an effort to create the largest open dataset of drug-protein interactions in history. More data → smarter AI models → better medicines gov.uk/government/new…

We're excited to partner with the UK Government on OpenBind, an effort to create the largest open dataset of drug-protein interactions in history.

More data → smarter AI models → better medicines

gov.uk/government/new…
Ari Wagen (@ariwagen) 's Twitter Profile Photo

Chai Discovery (Joshua Meier Chai Discovery) just released Chai-2, a model for "zero-shot antibody design in a 24-well plate." The most existing result? Chai-2 successfully generated binders for 50% of the 52 targets they assayed (100x better than SOTA)! Some thoughts below:

Chai Discovery (<a href="/joshim5/">Joshua Meier</a> <a href="/chaidiscovery/">Chai Discovery</a>) just released Chai-2, a model for "zero-shot antibody design in a 24-well plate."

The most existing result? Chai-2 successfully generated binders for 50% of the 52 targets they assayed (100x better than SOTA)!

Some thoughts below:
Biology+AI Daily (@biologyaidaily) 's Twitter Profile Photo

Chai-2: Zero-shot antibody design in a 24-well plate 1.Chai-2 is a multimodal generative model for protein design that achieves a 16% hit rate in fully de novo antibody generation—over 100x higher than previous methods—without requiring high-throughput screening. 2.In a

Matt McPartlon (@mattmcpartlon1) 's Twitter Profile Photo

It's been a privilege work alongside the most uniquely talented group of individuals I've ever encountered on this breakthrough result Kevin Wu, Nathanael Rollins, Jacques Boitreaud, danny, Jack Dent , Joshua Meier, Zhuoran Qiao / 乔卓然 and others. You all made this possible!

Kenny Workman (@kenbwork) 's Twitter Profile Photo

Some scientists see the increasingly impressive results from protein binding models and argue "solving" this problem actually has marginal return on an end-to-end drug campaign in practice. Generally, they claim (1) traditional immunization / hybridoma assays are already quite

Menlo Ventures (@menloventures) 's Twitter Profile Photo

🚀 Welcome to the portfolio, Chai Discovery! Their Chai-2 model achieved a 100x improvement in antibody design. This is how you transform drug discovery. Thrilled to back this world-class team: Joshua Meier Jack Dent Matt McPartlon Jacques Boitreaud For more on why we invested👉

🚀 Welcome to the portfolio, <a href="/chaidiscovery/">Chai Discovery</a>!
Their Chai-2 model achieved a 100x improvement in antibody design. This is how you transform drug discovery. Thrilled to back this world-class team: <a href="/joshim5/">Joshua Meier</a> <a href="/_jackdent/">Jack Dent</a> <a href="/Mattmcpartlon1/">Matt McPartlon</a> <a href="/j_boitreaud/">Jacques Boitreaud</a> 

For more on why we invested👉
Matt McPartlon (@mattmcpartlon1) 's Twitter Profile Photo

Beyond excited to welcome Dr. Mikael Dolsten to the Chai Discovery board. His leadership in bringing transformative medicines to patients is unmatched, and we’re thrilled to have his guidance as we scale Chai-2 and beyond!