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Why are so many inherited traits not explained by genome sequence variation? In my PhD work with @wbderry we describe a new mechanism of inheritance in animals that may account for this ‘missing heritability' 🧵nature.com/articles/s4155…

Not DNA Not RNA Not even epigenetic marks Inherited amyloid proteins nature.com/articles/s4155…

😮😮🤯 "...heritable amyloids across generations, which enables proper germ cell sex differentiation. We propose that inheritance of a proteinaceous epigenetic memory coordinates developmental timing and patterning with the environment to confer adaptive fitness."

Excited to share that I’ve been awarded a fellowship from the American Parkinson Disease Association (APDA)! Huge thanks to APDA for the generous support and to my mentor, Dr. Lorenz Studer, for his guidance! American Parkinson Disease Association Lorenz Memorial Sloan Kettering Cancer Center

Thank you for the interest in our work! Happy to answer any questions if I can…

💫NEW: @wbderry, Matthew Eroglu & co describe protein amyloid structures that are stably inherited across generations and transmit #EpigeneticMemory in C. elegans. MSTR protein loss results in #transgenerational feminization through ectopic GLD-1 expression. nature.com/articles/s4155…

Noncanonical inheritance of phenotypic information by protein amyloids: nature.com/articles/s4155…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

👋Our October issue's out! Cover: Heritable #Amyloids 👉🏻Comment on #EmbryoModels 👉🏼Review: #mitophagy #pink1 #neuroprotection 🔬on: #gastruloids #mechanobiology #Golgi #polycomb #epigenetics #HSF1 #antitumor #Pbodies #cancer & more! nature.com/ncb/volumes/26…

Delighted that our image was selected as cover for the October issue of Nature Cell Biology

Our neurotransmitter atlas is officially published! This final version includes a lot of extra data (incl. in suppl. files) that weren't in the earlier versions, but I think they could be useful—feel free to check them out! #neurotransmitter #celegans elifesciences.org/articles/95402…

MoGen researchers at University of Toronto found that amyloids—proteins tied to diseases like #Alzheimers—can influence heritable traits in C. elegans w/o DNA changes. Published in Nature Cell Biology. Study led by @wbderry and Matthew Eroglu Read👉 uoft.me/HeritableAmylo… #Epigenetics #DNA

The origin story of Parafilm

"Leaving sticky notes for the children" - Here's a new "Dispatch" @EthanEwe and I wrote in Current Biology about the super cool discovery that Matthew Eroglu and Brent Derry had about transgenerational amyloids! (published recently in Nature Cell Biology) authors.elsevier.com/a/1kCED3QW8S6G…

Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes biorxiv.org/content/10.110…

Small but significant results that led to our amyloid inheritance study “Regulation of MAP Kinase signaling by the insulin-like growth factor pathway during C. elegans vulval development” micropublication.org/journals/biolo…

Congratulations to the 2025 #LeonLevyScholars!🎉 Announcing the 2025 #LeonLevyScholars, in partnership with the Leon Levy Foundation. Recipients participate in a multi-year postdoctoral program to advance their careers. Read more about the Scholars: bit.nyas.org/3Yoa6Pf

Very grateful to the NYAS for supporting me with the Leon Levy fellowship for my postdoctoral work Columbia University

Congratulations to all our Columbia University scientists recognized with NYAS 2025 Leon Levy Scholarships in Neuroscience: Matthew Eroglu, Yuki Haba, Sreejan Kumar, Yuta Mabuchi and Keshav Suresh. 👏 👏👏

We are pleased to congratulate Matthew Eroglu of Columbia University on joining the 2025 cohort of #LeonLevyScholars in partnership with the Leon Levy Foundation. 👏 Learn more about Matthew & meet each of the Scholars in our latest press release. Read more: bit.nyas.org/3Yoa6Pf