Redefining the architecture of ferlin proteins: insights into multi-domain protein structure and function biorxiv.org/cgi/content/sh… #biorxiv_biophys

Pathogenic Mutations in the C2A Domain of Dysferlin form Amyloid that Activates the Inflammasome. biorxiv.org/cgi/content/sh… #biorxiv_biophys

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" biorxiv.org/content/10.110… We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during vesicle fusion ❄️🔬⏱️

Synaptotagmin-1’s C2 domains are like Jenga towers: the AD3 spot is that one crucial block holding it all together! Pull it wrong, and the whole structure wobbles. Dominguez et al. shows how this tiny locus controls domain stability. ow.ly/Ga5P50W3qi8