Introducing ECS member Björn-Philipp Diercks Björn-Philipp Diercks: ECS junior board member and spokesperson! #ECSmemberprofile #jECSboard For more information about Björn’s research at UKE, Germany UKE Hamburg: fis-uke.de/portal/de/pers…

Introducing ECS member Silke Chalmers: ECS junior board member! #ECSmemberprofile #jECSboard Silke conducts her research University of Queensland, Australia.

#ECSWebinar this Thursday! Talk 1 of 2: "Seeing Ca2+ in cryoEM data: from blobology to biology" by Geoffrey Woollard See webinar schedule for details: bit.ly/3pV8qsK

Introducing ECS member Adelina Ivanova Adelina Ivanova: ECS junior board member! #ECSmemberprofile #jECSboard For more information about Adelina’s research at University of Cambridge: phar.cam.ac.uk/directory/miss…

I'm really proud of this project

Introducing ECS member Tim Vervliet: ECS junior board member! #ECSmemberprofile #jECSboard For more information about Tim’s research at KU Leuven, Belgium KU Leuven: kuleuven.be/wieiswie/en/pe…

Today is the #ECSWebinar one year anniversary! Huge thank you to all those who have attended and supported our 26 wonderful speakers and counting... For more information on past and present webinars: bit.ly/3pV8qsK

The first webinar was presented by Don Gill on 14th May 2020. Recordings of Don’s talk and many others can be found on the jECS YouTube channel: tinyurl.com/2hc842f5

"This is Olympic spirit!" Lotte Miller consoles Claire Michel - the final athlete to cross the finish line in the women's triathlon ❤️ #Tokyo2020 | #Triathlon

Here are the four session topics for the #jECS2021 meeting! We're open for abstract submission here: forms.gle/fPgA9K59WDZwAh… - deadline September 15! We select posters and 12 talks from abtracts! 🤩

#Signalling and #calcium signalling enthusiasts - you are all cordially invited to this exciting 'science-day-out' in a scenic setting of Queens' college, Cambridge Martin Bootman MarchantLab open.ac.uk/stem/life-heal…

Tired but satisfied after 3 days of exciting in-person CaSign WOG event supported by FWO and Hamamatsu Photonics (with eg LLEW RODERICK; Laboratory Of Ion Channel Research - Leuven) filled by excellent talks from ECR’s and international in-person attendees Martin Bootman Joachim Goedhart

Great work from the OU! Support for Ukrainian refugees and for host families. ounews.co/around-ou/univ…

Jeez. In the first 30 minutes of tonight’s Tory leadership debate Rishi Sunak & Liz Truss managed to completely eviscerate the whole Tory Government Watch in disbelief

A special word to … Martin Bootman. Thanks AV-man! 🤣 🙏 MaleneBrohus and Björn-Philipp Diercks for many small & big things and your continuing enthusiasm & support with jECS Board! 🙏 @T_Luyten for all your help throughout! Definition of friends: they help out without asking! 🙏

What better way to the start the week than by reading our amazing new #AppNote, with many thanks to Martin Bootman. Find out how he used rapid, high resolution #fluorescence measurement techniques to study mitochondrial membrane flickers... lnkd.in/ecBfbPPW #microscopy

Happy to share CDD press paper by Flore Sneyers identifying PFKFB3 enzyme as direct target of intracellular Ca2+ chelator, thereby accounting for Ca2+-independent inhibition of mTORC1, MCL-1 downregulation and cell death in MCL-1-addicted cells! rdcu.be/dlClz

Science requires proper controls. BAPTA evoked MCL-1 downregulation, so "Ca2+ drives MCL-1 abundance"? It turned out that TF-BAPTA (Kd 65 µM, far off 100 nM basal [Ca2+]) too evoked MCL-1 decline! So, Ca2+ chelation was not the cause. Our journey led to direct PFKFB3 inhibition!

#calcium #BAPTA #controls #PFKFB3 #MCL1 #cell_death jECS It wasn't easy and risky working on an "off-target". But, we found it worthwhile to properly interpret findings as BAPTA is used in >1000s studies but also learning new things such as PFKFB3 linking to MCL-1.

The review is the product of truly great, inspirational and collaborative endeavor with our 2 PhD students (Flore Sneyers & Femke Speelman-Rooms) and our ChemBio partner VerhelstLab and Calcium partner Martin Bootman! 🙏for your help, input & feedback throughout the work!