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ASCOLT trial was negative, but here’s another trial for aspirin as an adjuvant for colorectal cancer. ALASCCA was biomarker driven - only patients with PI3K pathway mutation were included. 👉 >50% reduction for recurrence with aspiring. This is HUGE!

Systematic review of the impact of anastomotic leak after CRC surgery on AOL. Read more in #DCRJournal: bit.ly/4hhsQaz

A man can die but once, but the surgical community have used different metrics for postoperative fatalities ➡️doi.org/10.1093/bjsope… In this registry-based study, the authors refined a statistical framework using declining hazards. Applying this to elective colorectal cancer

In what is surely the crowning achievement of a middling colorectal surgeon from the periphery, I finally get to quote Shakespeare! On a more serious note, this would be really interesting to replicate for other procedures. What is postoperative mortality? Umeå University

SELective defunctioning Stoma Approach in low anterior resection for rectal cancer (SELSA): Protocol for a prospective study with a nested randomized clinical trial investigating stoma‐free survival without major LARS following total mesorectal excision onlinelibrary.wiley.com/doi/full/10.11…

#DCRJournal Visual Abstract | Long-term Outcome After Surgical Resection of Para-aortic Lymph Node Metastasis of Colorectal Cancer: A Multicenter Retrospective Study: bit.ly/4hcaCYu

Thanks for highlighting our trial, recruiting since September 2024. More centres open this year and hopefully we’ll meet our inclusion target in 2027. Much to do and learn about defunctioning stomas! Cancerfonden and Vetenskapsrådet have generously funded the trial.

Short-term outcomes from the ‘Watch and Wait’ (WoW) study: prospective cohort study ➡️doi.org/10.1093/bjsope… This prospective multicentre observational study included patients who, following neoadjuvant treatment for rectal cancer, obtained a clinical complete response and were

Rectal cancer surgery: radiology roadmaps ➡️ doi.org/10.1093/bjs/zn… 1⃣Based on radiological imaging, a ‘radiology roadmap’ succinctly describes how rectal cancer could be potentially resected with a high probability of histologically clear (R0) margins 2⃣Radiology roadmaps are

SELective defunctioning Stoma Approach in low anterior resection for rectal cancer (SELSA): Protocol for a prospective study with a nested randomized clinical trial investigating stoma‐free survival without major LARS following total mesorectal excision onlinelibrary.wiley.com/doi/full/10.11…

#DCRJournal Letter to the Editor | Rectum, Mesorectum and Infra-Mesorectum Radical Excision in Low Rectal Cancer: bit.ly/43QJSIA Author Reply: bit.ly/4kWSXWv Martin Rutegard

Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database ➡️ doi.org/10.1093/bjs/zn… This first prospective observational study evaluates the impact of

🇬🇧PRIME-RT results ESTRO today: Durvalumab anti-PDL1+SC/LC TNT in #rectalcancer 52% of pts had CR (pCR/cCR) @ 6mth post-EOT in LARC ⬆️CR rate w SCRT-Durv - may reflect divergent immune effects of RT on TME Privileged to be part of incredible ‘Top trials’ session#ESTRO25

New trial coming up - PROSPERITY trial comparing protective ileostomy versus colostomy in anterior rectal resection. Presented at European Society of Coloproctology. Protocol now out in BMJ_Open! Trial is open for new centers also! Contact Laura Koskenvuo if interested! bmjopen.bmj.com/content/bmjope…

Thomas Korgaard Jensen European Society of Coloproctology BMJ_Open Laura Koskenvuo Toni Seppälä Young ESCP Neil Smart Great question, which really didn’t fit into this trial. Some (but not all) patients might do better without a stoma. This is assessed in SELSA trial by Martin Rutegard et al, see 👉 pubmed.ncbi.nlm.nih.gov/39887540/ PROSPERITY is about ’if you need a stoma, which one should it be?’

New 🇫🇮🇳🇴RCT out JAMA Surgery 🔥 Results from antibiotics layer of the PERFECT trial: Antibiotics or no while awaiting for appendectomy for presumed uncompl appendicitis 1797 patients Perforations: 8.3% vs 8.9% Surg site infections: 1.6% vs 3.2% (p=0.03) jamanetwork.com/journals/jamas…

So, many are mulling over how to interpret the results of PERFECT-Antibiotics trial. I will share my thoughts in a thread 🧵

So this is interesting: Opinions among responders are exactly 50:50 antibiotics vs no antibiotics while awaiting appendectomy for presumed uncomplicated appendicitis 🤔 Even when you have the best data available, it’s still not self-evident how to interpret the evidence

Routine use of indocyanine green fluorescence imaging does not decrease the overall rate of anastomotic leak in laparoscopic colorectal surgery if low anterior resections are not included. ja.ma/4jzvWHv

Exposure to androgen deprivation therapy and risk of anastomotic leakage after colorectal cancer surgery onlinelibrary.wiley.com/doi/full/10.11… open access Colorectal Disease