Mechanism of RanGTP priming the release of H2A-H2B from Kap114 and Importin-9 biorxiv.org/cgi/content/sh…

The Kurumizaka ERATO project is organizing a virtual International Symposium titled "Chromatin Architecture: Structure and Function" on Jan. 24-25, 2023. Registration is open now! Deadline for abstracts submission for posters is Jan. 9, 2023. Check it out! bit.ly/3XPvQS8

The Effects of Histone H2B ubiquitylations and H3K79me3 on Transcription Elongation biorxiv.org/cgi/content/sh… #bioRxiv

Congrats to Shawn and team!! First we learn from @LugerLab about eukaryotic histones…then virus…and now…bacteria!?!? What next???

Exciting complimentary nucleosome-SIRT6 work by Jean-Paul Armache, Song Tan and Craig Peterson labs: biorxiv.org/content/10.110… Interesting differences in H2A dynamics in the absence of NAD vs. our catalytically poised state. Our story: pubs.acs.org/doi/10.1021/ja…

I’m excited to share a new manuscript on Sirtuin6-nucleosome structure, a result of a great collaboration between Peterson Lab, Song Tan’s, and Jean-Paul Armache labs. /1 biorxiv.org/content/10.110…

Binding to nucleosome poises SIRT6 for histone H3 de-acetylation biorxiv.org/cgi/content/sh…

So excited to share that my thesis work is out now at Molecular Cell! Karen AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY3vVUPNx…

Congratulations to Farnung lab PhD Candidate Felix Steinruecke! He has been selected to receive a 2023 NSF Graduate Research Fellowship. Amazing!

Mechanism of histone H2B monoubiquitination by Bre1 biorxiv.org/content/10.110…

Our latest publication reports the cryo-EM structures of the human Polα-Primase DNA elongation complexes - rdcu.be/c96yY A Lim lab X Tahirov lab collaboration led by Qixiang He 贺琦翔 and Andrey. Thank you, Sara Osman & NatureStructMolBiol, for working with us! Please RT to share! 1/4

Our story on the complete Rpd3S-nucleosome complex is now online on Biorxiv: biorxiv.org/content/10.110… We visualize the S. cerevisiae Rpd3S complex bound to a nucleosome including the "evasive" Ume1 subunit! Congrats, Jon Markert! Thank you Seychelle Vos for a great collaboration.

Our paper on the structure of the complete Rpd3S-nucleosome complex is now out in Nat Comm: rdcu.be/ds6k1. Congrats to Jon Markert and co-corresponding author Seychelle Vos ! This is the second HDAC-nucleosome structure from Jon this year. Amazing!

Congratulations Melissa Hoyer and everyone else involved!

biology methods for understanding protein post-translational modifications in cancer & aging. Excited for this new journey! Looking to hire passionate postdocs, technicians, and grad students. Join us! [Main Webpage: zawanglab.com] #research #Careers

I am happy to share that I will be starting an assistant professor position at the Van Andel Research Institute Van Andel Institute (VAI) in the Department of Neurodegenerative Science. My lab is opening in July, and I am currently hiring: vai.wd1.myworkdayjobs.com/en-US/VAICaree… and vai.wd1.myworkdayjobs.com/en-US/VAICaree…

Hiring! Seeking motivated postdocs, technicians, and graduate students for our new lab at the University of Miami Miller School of Medicine. Dive into protein chemistry and chemical proteomics to explore cancer and aging. #ZwangLab #UMiami #Research zawanglab.com

Excited that our work on transcription-coupled DNA repair is now published Cell! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸 ➡️ cell.com/cell/fulltext/…

Our work providing the mechanistic basis for SETD2 function is finally out! We demonstrate SETD2 requires active transcription to facilitate H3K36me3 deposition!

I’m very happy to share our latest work on the ParABS system. We investigated the dynamic interaction between the ATPase ParA and the CTPase ParB mediating chromosome segregation in Myxococcus xanthus. I would like to thank all the people involved.