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Hard to have sympathy for this (whilst remaining very sympathetic for current US based researchers having a terrible time). Reversing the brain drain will have positive global impacts outside US x.com/TheAtlantic/st…

Remember in December 2023 when Prof Colin R Melville GMC denied there would be bulk approval of PA courses? …until he knew a minuted meeting confirmed this? We now have news of bulk approval of PA courses without waiting for The Leng review and with no rigorous quality standards These

The Us deciding it doesn’t want to lead international collaborative science is a once in a generation opportunity to other countries funders… who will step into the void?nature.com/articles/d4158…

What went so wrong with all previous generations that my kids always having to have a water bottle with them is going to fix?

I’ve done my best ever exemplar of thinking like a mediocre white man. When pointed out I was wrong on a thing I basically said ‘no I’m right, but just not as right as I could be’ 🤣😂🤣

A very thoughtful & lovely editorial on our UK imatinib study in pulmonary hypertension. Alex Rothman atsjournals.org/doi/pdf/10.116…

🌍 Today is #WorldPHDay2025 and it’s a chance to make our voices heard across the globe. These are just a few stories from our UK community which show how #PulmonaryHypertension can affect anyone: phauk.org/HearUs. There are many, many more stories to tell.

Following an article from British Heart Foundation about the £5 blood test that improves risk prediction for heart attacks and strokes, we caught up with the lead analysis behind the idea. BHF Cardiovascular Epidemiology Unit at Cambridge Cambridge University

3 for the price of 1 in this paper! … very pleased to see the cumulation of three thesis chapters in print … PhD still in progress… hopefully more to come…. doi.org/10.1183/160006… #PROMS #PH #PAH

📢 Announcing the PVRI 2026 Scientific Organising Committee! We’re excited to introduce our fantastic team shaping the scientific programme for #PVRI2026, taking place 28–31 January 2026 in Dublin. This global group of experts will bring together diverse perspectives across basic

Of the estimated 20,000 human gene products ~4,400 are thought to modify human disease. But if your protein isn’t one of the ~650 targeted by approved therapies…how do you drug it❓Out today Cell cell.com/cell/fulltext/…

Pulmonary arterial hypertension is a rare disease caused by BMPR2 mutation & reduced BMP signalling. Catherine, Nick, Marc.

A while back we showed SMURF1 was increased in PAH and reduced BMP signalling, and SMURF1 deletion prevented experimental disease. jci.org/articles/view/…

Small problem… SMURF1 is a HECT E3 ligase with no active site binding pocket, so we couldn’t do a computational screen to identify early inhibitors.🤔

But they were right, turns out the flexible amino acid at the elbow of the hinge is the same in all HECT E3’s, across animal, plant, and fungal kingdoms.

In the latest issue! Therapeutic potential of allosteric HECT E3 ligase inhibition dlvr.it/TKqmbX

This time last week, super supporter Natasha Hinton was making her way around a hot and hilly Leeds Marathon - with every stride dedicated to the memory of her friend Yan. Natasha has raised over £1,300 for our charity in his name, and we're so, so grateful 🙏 #TeamPH

Is Scotland the only place where Irn Bru counts as one of your 5 a day?